Midazolam & Seizures - Essay Example

Pathophysiology of Epilepsy Epilepsy is caused due to neurological dysfunction where abnormal neuronal firing give way to changes in the functioning of sensory perception, motor control, autonomic function. The clinical manifestation of epilepsy is seizure. As per (Stafstrom,2000) “ Epilepsy is the condition of recurrent spontaneous seizures arising from aberrant electrical activity within the brain”. The pathogenesis of epilepsy is still not known.Mechanism of MidazolamThe mechanism of Midozolam is supposed to be mediated through the inhibitory neurotransmitter gamma – aminobutyric acid (GABA) which is one of the main inhibitory neurotransmitter in the brain.

Midozolam increases the activity of GABA which gives a calming effect to the user. It also relaxes the skeletal muscles and result in sleep. The chemical in the medicine called benzodiazepines bind to the receptors of GABA which enhances the effect of GABA by increasing the frequency of chloride channel opening.Pathophysiology of MidazolamAccording to (Silver,1994,pg 350-60) “Midazolam is a potent imidazobenzodiazepine used as a premedicant and as an anesthetic induction Agent”.Midazolam is likely an agonist at both BZ1 and BZ2 receptors.

Its performance at PBRs is not certain. The quick encephalopathic effects ofmidazolam may be connected to the trizolam like potency and lipophilicity of midazolam. Which are greatest among thebenzodizepines. Midazolam may also exert some anticholinergic activity.Dose adult and children of MidazolamAdult maximize dosage can go up to 6mgInfants till 6 months not recommended.Children from 6 months to 5 yrs - .6 mg/kgChildren from 6 – 12 yrs - .4mg/kgReferencesStafstrom,C. 2010. Pathophysiology of seizures and epilepsy .

[ONLINE] Available at: http://www.uptodate.com/contents/pathophysiology-of-seizures-and-epilepsy. [Accessed 28 August 13]. Silver, T, 1994. SCIENTIFIC ARTICLE Evaluation of two dosages of oral midazolam as a conscious sedation for physically and neurologically compromised pediatric dental patients. Pediatric Dentistry, 16/5, 350-360.