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Reasons for Modifying the Surface of a Gold/ Deminder Nanocomposite Targeted System - Assignment Example

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This paper "Reasons for Modifying the Surface of a Gold/ Deminder Nanocomposite Targeted System" focuses on the fact that gold nanoparticles are generally known for their cytotoxic effect on cells. They are reported to cause inflammation of the macrophages. …
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Reasons for Modifying the Surface of a Gold/ Deminder Nanocomposite Targeted System
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As opposed to Gold nanoparticles, PSMA proteins can be continuously recycled. When the PLGA-b-PEG (poly(D, L-lactic-co-glycolic acid)-_-(polyethene glycol) nanoparticles inside an A10 aptamer are loaded with cisplatin while using the NP system, it has been shown to improve tolerability which is efficacy in a xenograft model.
Gold nanocomposites have variable surface charge and adherence. Therefore, it is possible to modify it using a different type of strain of the gold nanocomposite. The DNC (Dendrimer nanocomposites) can only have a specific type of charge on the host polymer making them useful in mapping certain cell components.
Gold nanocomposite offers high electron density of the immobilized gold atoms used in imaging. There can be a modification of the interaction between nanoparticles and the biological environment by changing the number and character of the surface groups on the dendrimer. This can be easily modified as for better visualization using an electron microscope.
Gold nanoparticles that have been modified using N, N, N-trimethyl(11-mercaptoundecyl) ammonium chloride have a property of binding on pDNA effectively. This, however, requires the presence of an endosmotic agent like chlorine that will help in the competent transfection of various cell lines.
Characteristics that ais critical to control for the gold/dendrimer packet meant to target all cancer cells without causing minimal damage to the surrounding tissues should be measured. In order to achieve this, the Zena potential and the size of the particles are factored in. The following characteristics are determined using.
1) DNA mobility shift assay
2) In vitro transfection studies
3) DNase protection assay
4) MTT based cell metabolic activity
5) DNA retardation assay.

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