The Effects of Indomethacin Administration - Essay Example

It should not be taken when the patient is in the active condition of bleeding, or if the patient is drug allergic. Indomethacin also has some risk factors for pregnant patients. It should be avoided if the patient is in the pregnancy’s third trimester. “In the fetus, indomethacin has been reported to cause constriction of the ductus serious… and decreased urine output … frequently resulting in oligohydramnios” (Norton, 1997, p. 283). Indomethacin exposes the neonate to a lot of risks that include but are not limited to pulmonary hypertension, ileal perforation, persistent ductus arteriosus, and intracranial hemorrhage (Norton, 1997, p. 283). Contraindications of Indomethacin include active bleeding, renal impairment, aortic coarctation, thrombocytopenia, and necrotizing enterocolitis in neonates.

Side effects of indomethacin include pain in the injection site, redness, severe allergy in the form of hives, rashes, itching, tightness in the breast, swelling on the tongue, face, or any feature of the face, blood in urine, stool or vomit, and decreased heartbeat rate. The dosage of indomethacin varies from case to case depending on the disease. The dosage recommended for the treatment of osteoarthritis and rheumatoid arthritis is 25 mg twice or thrice a day.