Contact Us
Sign In / Sign Up for FREE
Go to advanced search...

Beta-Blockers for Acute Myocardial Infarction - Essay Example

Comments (0) Cite this document
The researcher of this essay aims to analyze the usefulness of beta-blockers, that is a short form of “beta-adrenergic receptor blocking agents” for acute myocardial infarction. This essay presents several studies and researchers, that were consucted on the topic…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER98.7% of users find it useful
Beta-Blockers for Acute Myocardial Infarction
Read TextPreview

Extract of sample "Beta-Blockers for Acute Myocardial Infarction"

Download file to see previous pages The subjects - survivors from a first AMI, were randomly assigned to two treatments. Thirty-seven patients received 100 mg metoprolol (a beta-blocker) per day whereas 34 patients received placebo. Before the study was conducted, a 24-hour ambulatory ECG was performed on each subject. This was repeated after 4 weeks of therapy. QT and RR intervals were determined through a computer program and the QT/RR relationship was described in terms of linear regression. The results showed that the regression lines significantly differed between the two study groups and metoprolol reduced the QT/RR slope. The authors concluded that long-term beta-blockade in MI patients results in "a reduction of the QT/RR slope with a prolongation of the QT interval at higher rates" (Hintze et al., 1998). This implies that patients treated with beta-blockers may benefit from decreased susceptibility to life-threatening arrhythmias. A subsequent study by Bonnemeier, Ortak, Tlg, Witt, Schmidt, Wiegand et al. (2005) compared the effects on QT-dynamicity of two beta-blockers - carvedilol and metoprolol in patients undergoing percutaneous coronary interventions (PCI) for MI. Data from 38 patients treated with metoprolol 200 mg/day and 34 patients treated with carvedilol 25 mg/day were subjected to QT/RR slope analyses. The data were gathered from a 24-hour ambulatory ECG recorded upon hospital admission and slopes of linear QT/RR regression were calculated before and after reperfusion. The results demonstrated no significant difference between the QT/RR slopes of the two groups before PCI. After PCI however, "there was a trend toward lower QT/RR slopes in the metoprolol groupand a significant decrease in the QT/RR slopes in the carvedilol group" (Bonnemeier et al.,...
This essay states that in the list of leading causes of U.S. deaths, heart disease ranks first and stroke ranks third. The British Heart Foundation states that myocardial infarction, also known as heart attack or coronary thrombosis, is a disease wherein the heart suddenly loses its blood supply. If not treated immediately, it can lead to the death of the affected area and consequently, the cessation of all heart functions. Most MIs happen to people over 50 and the incidence is higher in men than in women. Several treatments are available including aspirin and other platelet drugs, emergency angioplasty, heparin, and beta-blocker drugs. The term “beta-blocker” is a short form of “beta-adrenergic receptor blocking agents”. When used to treat acute myocardial infarction, it reduces oxygen supply, which is beneficial since this decreases myocardial workload and oxygen demand. Once a person has undergone an MI, beta-blocker is required for life. The results of the study showed that there was no significant difference in the incidence of MI between atenolol, placebo and other hypertensives. While the risk of stroke was 19% lower in the beta-blocker group, there were no differences noted for MI or all-cause mortality. Recent clinical trials suggest that beta-blockers are linked with increased risk of type-2 diabetes. However, beta-blockers are still valuable for heart rate control in patients with tachyarrhythmias and that the studies that contradict the effectiveness of beta-blockers do not apply to new ones.
...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
(“Beta-Blockers for Acute Myocardial Infarction Essay”, n.d.)
Beta-Blockers for Acute Myocardial Infarction Essay. Retrieved from
(Beta-Blockers for Acute Myocardial Infarction Essay)
Beta-Blockers for Acute Myocardial Infarction Essay.
“Beta-Blockers for Acute Myocardial Infarction Essay”, n.d.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document

CHECK THESE SAMPLES OF Beta-Blockers for Acute Myocardial Infarction

Acute Myocardial Infarction

.... Beta-Blockers have been shown to reduce mortality both in the early (hospital) and chronic post-AMI periods. In ISIS-1 atenolol was administered within 12 hours of diagnosis and reduced hospital mortality from 4.3% to 3.7%. Similar results were seen in the MIAMI trial and in TIMI-II, where early intravenous metoprolol (within 2 hours) followed by oral dosing is observed to reduce mortality, reinfarction, and recurrent ischemia. The benefits were evident by day 1 and were sustained throughout the follow-up period. Three large well-done randomized trials have demonstrated that institution of a beta-blocking agent prior to discharge for acute myocardial...
12 Pages(3000 words)Essay

Myocardial Infarction

...Myocardial Infarction Introduction. Myocardial infarctions or acute myocardial infarction (MI) is commonly called heart attack and is a serious disease of coronary which occurs due hardening or narrowing of arteries when cholesterol plaque builds up. Blockage of arteries leads to a major reduction of blood supply, consequently causing necrosis (death or damage) of heart muscles (myocardium) or myocardium ischemia as the heart muscles are not served with oxygenated blood for quite some time (Life nurses forum:Nursing care plans for Myocardial infarction (MI)) (Imagins website:The women health resource,Overview of myocardial infarction.). The infarction site depends on which vessels are involved. For example, if blockage occurs... .,...
4 Pages(1000 words)Research Paper

The Myocardial Infarction Case

... The Myocardial Infarction Case Study Introduction This essay covers a case study of 65-year old woman, Margo McCaffery, who is presented at an emergency department feeling sick. The essay covers mainly, the pieces of assessment data in support of diagnosis of acute myocardial infarction and an explanation of the pathophysiology of each piece of data. Myocardial infarction (MI) is also called heart attack, which occurs due to, the formation of occlusive thrombus after the rapture of an atheromatous plaque in a coronary artery...
8 Pages(2000 words)Essay

Myocardial Infarction

... with acute myocardial infarction to the administration of psychological instruments. Biol Res Nurs., 4(2), 85-91. Fenton, D.E. (2008). Myocardial Infarction. Emedicine from WebMD. Retrieved on 24th Feb, 2011 from Zevitz, M. E. (2006). Myocardial ischemia. Emedicine from WebMD. Retrieved on 24th Feb, 2011 from ?Case Study: Myocardial Infarction Pathophysiology Myocardial infarction occurs as a result of imbalance between the demand and supply of oxygen to the muscles of the heart that is critical enough to result in necrosis of the myocardium. This occurs due to...
3 Pages(750 words)Research Paper

Myocardial Infarction

...because of accumulation of atherosclerotic plaques. These plaques are basically thrombi composed of lipid foam cells (cholesterol) and different cell components including smooth muscle, macrophages and collagen fibres. In most instances, the ischemic myocardial infarction is precipitated by the phenomenon called acute plaque change. Acute plaque change results from the rupture of pre-existing thrombi that partially occlude the lumen. The rupture exposes the underlying thrombogenic endothelium. The plaques are also termed as vulnerable plaques as they contain lipids in high amounts, along with collagen fibres and inflammatory cells. When ruptured, the reactivity of these...
7 Pages(1750 words)Research Paper

Myocardial infarction

...? Myocardial Infarction Article one Myocardial infarction accelerates atherosclerosis Summary This article gives a report on the effect of myocardial infarction on atherosclerosis. The results are based on research information obtained from the use of mice in the investigation. As atherosclerosis progresses toward the acute stage, it triggers myeloid cells destabilization in the artery walls which makes them rupture. This cause stroke and infarction. This research shows that the response to ischemic damage makes acute atherosclerosis to get worse. The mice used in this experiment were...
3 Pages(750 words)Case Study

Acute Myocardial Infarction

.... The primary prescription routines include beta blockers (to restore heart rhythms), anti-thrombotics (generally dual anti-platelet therapies) and, in some cases, anti-depressants. For longer-term reduction in AMI risk, physicians will also prescribe primary AMI reduction medicines, particularly statins, and secondary risk factor reductions. The latter may include glucophage for diabetes patients, anti-inflammatories for patients with concerns for inflammation, and other such medicaments as needed. It is particularly important that the patients maintain their anti-platelet therapies. Those who have received a coronary stent and stop their dual anti-platelet therapies within 6 months risk a 7-fold...
5 Pages(1250 words)Essay

Myocardial Infarction

...Critical Analysis of Articles The purpose of this essay is documentation of critical analysis of two articles on myocardial infarction. One article is on diagnosis especially in critically ill individuals who were admitted to the intensive care unit (ICU) while the other article is on various options for managing a case of myocardial infarction. Although, the main topic of the two articles is the same, myocardial infarction, otherwise these two articles are entirely different as far as the type of articles is concerned. One article is based on the original research carried out in icu of a hospital setting but the second one is debate on the choices of different management strategies for a case of acute myocardial infarction... in that...
14 Pages(3500 words)Book Report/Review

Acute Myocardial Infarction

...Acute Myocardial Infarction (AMI) Pathophysiology Figure Summary of the pathological processes involved in AMI Plaque Formation V Plaque Rupture : V Thrombosis : V Myocardial Ischemia : V Myocardial Infarction The start of the pathophysiology of acute coronary syndromes like AMI lies in the formation of plaque. The American Heart Association has named these plaques as developed human fibrolipid plaques. Such plaques form as a result of low density lipoproteins being oxidized and consumed by macrophages. In this process the macrophages are transformed into foam cells, which accumulate within the smooth muscle cell layer...
2 Pages(500 words)Essay

Myocardial Infarction the determining factor of death of infarction, and increased oxygen supply to the site of blockage is believed to be a more effective instrument of salvaging the heart muscle, compared to reducing oxygen demand (Sharis & Cannon 2003). A whole set of modifiable risk factors contributes to the development of myocardial infarction risks in different population groups – smoking, diabetes, obesity and inactivity, and hypertension are, probably, the most important factors to consider in the discussion of myocardial infarction. Pathogenesis The onset of acute myocardial infarction usually occurs in the...
10 Pages(2500 words)Essay
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.

Let us find you another Essay on topic Beta-Blockers for Acute Myocardial Infarction for FREE!

Contact Us