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Oral Controlled Release System of Propranolol Using Gellan Gum Macrobeads with Magnesium Aluminum Silicate (veegum) - Dissertation Example

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Ionotropic gelation is based on the ability of polyelectrolytes such as gellan gum to cross link in the presence of counter ions, like Calcium (Ca2+) and Zinc (Zn3+) ions, to form hydrophilic hydrogel beads (gelispheres)…
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Oral Controlled Release System of Propranolol Using Gellan Gum Macrobeads with Magnesium Aluminum Silicate (veegum)
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Download file to see previous pages Gellan gum is a bacterial exopolysaccharide prepared by aerobic submerged fermentation of Sphingomones Eloda. Gellan gum, being a natural polymer, has an advantage as a drug delivery system because it induces less adverse reactions compared to the synthetic ones. It contains anionic moieties on its chemical structure, combines with the counter cations to induce gelation by cross linking. This polymer is unique in that when a concentrated solution of gellan gum is exposed to high temperatures, gelation is induced. Gradually decreasing the temperature allows the random coils of its structure to form organized double helices, which promote the formation of ordered junction zones. To allow determination of PPN concentration from absorbance measurements, a calibration curve was made by getting the absorbance of standard solutions with known concentrations. The resulting mathematical equation relating PPN concentration with its absorbance at 289 nm should help in determining the PPN concentration of the solutions to be obtained in the next parts of the experiments. Preparation of standard solutions First, the stock solution was prepared by diluting 10mg of PPN in 50ml of 2% EDTA solution. 1ml of stock solution was mixed with 9 ml of 2% EDTA solution. Subsequent dilutions were made based on the following table. No Total 1 1ml of Stock 2 1ml of 2%EDTA solution 2ml 2 1ml of Stock 2 4ml of 2%EDTA solution 5ml 3 1ml of Stock 2 9ml of 2%EDTA solution 10ml 4 1ml of number (3) 1ml of 2%EDTA solution 2ml 5 1ml of number (3) 4ml of 2%EDTA solution 5ml 6 1ml of number (3) 9ml of 2%EDTA solution 10ml UV Spectrophotometry The solutions then underwent UV Spectrophotometry in order to measure their absorbance of light at 289 nm. Since PPN readily absorbs light at this wavelength, the absorbed light increases with increasing amounts of PPN present in the solution. This is why UV Spectrophotometry is used to measure the concentration of a solution. Briefly, each dilution placed on a clear cuvette was loaded into the spectrophotometer (fig. 1), which will apply 289 nm light on the solution, while subsequently measuring the liquid’s absorbance. Fig. 1 UV-160A used to measure the absorbance at 289nm. After measuring the absorbance of each solutions at 289 nm using UV106, the points were plotted, with the concentration at x-axis, and the absorbance at y-axis. The equation that plots the curve was then obtained. Preparation of PPN-MAS complex dispersion Suspension of 8% (w/v) MAS was prepared using hot, sterile double deionised water (50 ml in 60?C) and cooled prior to use to room temperature. Then, 4.7, 9.4, and 18.8, volumes of this suspension were each added with 25 ml of the 1% w/v PPN double deionised to produce MAS concentrations of 0.75, 1.5%, or 3% (w/v), respectively. Finally, PPN was allowed to adsorb onto each of the MAS solutions by incubating them in a sterile environment at room temperature for 24 hours. Preparation of GG dispersions with PPN-MAS complexes To add in the delivery system, 0.5g GG was gently added to 50ml of sterile double deionised water. It was then heated to 55?C to allow the gellan gum to be hydrated. After cooling the dispersed GG in room temperature, the different PPN-MAS complexes of various MAS concentrations, which were prepared in the previous section, were centrifuged for 15mins using Centrifuge 5702 (fig. 2). This was done to remove uncoupled PPN and MAS (in the supernatant) from PPN-MAS complexes (in the solid layer). After pouring off the supernatant into a separate beaker, the solid layer of each was mixed with the GG dispersion at constant stirrer, 500rpm, until a homogenous dispersion was ...Download file to see next pagesRead More
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