StudentShare
Contact Us
Sign In / Sign Up for FREE
Search
Go to advanced search...

Oral Controlled Release System of Propranolol Using Gellan Gum Macrobeads with Magnesium Aluminum Silicate (veegum) - Dissertation Example

Comments (0) Cite this document
Summary
Ionotropic gelation is based on the ability of polyelectrolytes such as gellan gum to cross link in the presence of counter ions, like Calcium (Ca2+) and Zinc (Zn3+) ions, to form hydrophilic hydrogel beads (gelispheres)…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER94.4% of users find it useful
Oral Controlled Release System of Propranolol Using Gellan Gum Macrobeads with Magnesium Aluminum Silicate (veegum)
Read TextPreview

Extract of sample "Oral Controlled Release System of Propranolol Using Gellan Gum Macrobeads with Magnesium Aluminum Silicate (veegum)"

Download file to see previous pages Gellan gum is a bacterial exopolysaccharide prepared by aerobic submerged fermentation of Sphingomones Eloda. Gellan gum, being a natural polymer, has an advantage as a drug delivery system because it induces less adverse reactions compared to the synthetic ones. It contains anionic moieties on its chemical structure, combines with the counter cations to induce gelation by cross linking. This polymer is unique in that when a concentrated solution of gellan gum is exposed to high temperatures, gelation is induced. Gradually decreasing the temperature allows the random coils of its structure to form organized double helices, which promote the formation of ordered junction zones. To allow determination of PPN concentration from absorbance measurements, a calibration curve was made by getting the absorbance of standard solutions with known concentrations. The resulting mathematical equation relating PPN concentration with its absorbance at 289 nm should help in determining the PPN concentration of the solutions to be obtained in the next parts of the experiments. Preparation of standard solutions First, the stock solution was prepared by diluting 10mg of PPN in 50ml of 2% EDTA solution. 1ml of stock solution was mixed with 9 ml of 2% EDTA solution. Subsequent dilutions were made based on the following table. No Total 1 1ml of Stock 2 1ml of 2%EDTA solution 2ml 2 1ml of Stock 2 4ml of 2%EDTA solution 5ml 3 1ml of Stock 2 9ml of 2%EDTA solution 10ml 4 1ml of number (3) 1ml of 2%EDTA solution 2ml 5 1ml of number (3) 4ml of 2%EDTA solution 5ml 6 1ml of number (3) 9ml of 2%EDTA solution 10ml UV Spectrophotometry The solutions then underwent UV Spectrophotometry in order to measure their absorbance of light at 289 nm. Since PPN readily absorbs light at this wavelength, the absorbed light increases with increasing amounts of PPN present in the solution. This is why UV Spectrophotometry is used to measure the concentration of a solution. Briefly, each dilution placed on a clear cuvette was loaded into the spectrophotometer (fig. 1), which will apply 289 nm light on the solution, while subsequently measuring the liquid’s absorbance. Fig. 1 UV-160A used to measure the absorbance at 289nm. After measuring the absorbance of each solutions at 289 nm using UV106, the points were plotted, with the concentration at x-axis, and the absorbance at y-axis. The equation that plots the curve was then obtained. Preparation of PPN-MAS complex dispersion Suspension of 8% (w/v) MAS was prepared using hot, sterile double deionised water (50 ml in 60?C) and cooled prior to use to room temperature. Then, 4.7, 9.4, and 18.8, volumes of this suspension were each added with 25 ml of the 1% w/v PPN double deionised to produce MAS concentrations of 0.75, 1.5%, or 3% (w/v), respectively. Finally, PPN was allowed to adsorb onto each of the MAS solutions by incubating them in a sterile environment at room temperature for 24 hours. Preparation of GG dispersions with PPN-MAS complexes To add in the delivery system, 0.5g GG was gently added to 50ml of sterile double deionised water. It was then heated to 55?C to allow the gellan gum to be hydrated. After cooling the dispersed GG in room temperature, the different PPN-MAS complexes of various MAS concentrations, which were prepared in the previous section, were centrifuged for 15mins using Centrifuge 5702 (fig. 2). This was done to remove uncoupled PPN and MAS (in the supernatant) from PPN-MAS complexes (in the solid layer). After pouring off the supernatant into a separate beaker, the solid layer of each was mixed with the GG dispersion at constant stirrer, 500rpm, until a homogenous dispersion was ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
  • CHICAGO
(“Oral Controlled Release System of Propranolol Using Gellan Gum Dissertation”, n.d.)
Oral Controlled Release System of Propranolol Using Gellan Gum Dissertation. Retrieved from https://studentshare.org/health-sciences-medicine/1469209-formulate-an-oral-controlled-release-system-of
(Oral Controlled Release System of Propranolol Using Gellan Gum Dissertation)
Oral Controlled Release System of Propranolol Using Gellan Gum Dissertation. https://studentshare.org/health-sciences-medicine/1469209-formulate-an-oral-controlled-release-system-of.
“Oral Controlled Release System of Propranolol Using Gellan Gum Dissertation”, n.d. https://studentshare.org/health-sciences-medicine/1469209-formulate-an-oral-controlled-release-system-of.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document

CHECK THESE SAMPLES OF Oral Controlled Release System of Propranolol Using Gellan Gum Macrobeads with Magnesium Aluminum Silicate (veegum)

Budgetary Control and Costing System

Job costing and Process Costing are the two basic methods of costing. Job costing is suitable to industries, which manufacture or execute the work according to the specifications of the customers. Process costing is suitable to industries where production is continuous and the units produced are identical. All other methods are combinations, extensions or improvements of these basic methods.

1. JOB COSTING: It is also called specific order costing. It is adopted by industries where there is no standard product and each job or work order is different from the others. The job is done strictly according to the specifications given by the customers and usually, the job takes only a short time for completion. The purpose of...
17 Pages(4250 words)Case Study

Comparison of the Cold War International System to the Current International System

An example is that of the Korean War (1950-53) which is said to transform the nature of the Cold War, while its initial impact was to solidify the division of the world into political, military, and economic spheres. Take Germany for instance where imperialism was a victim challenged by the historians for the destruction of the German Government along with its supporters used to conduct (Keylor, 2001, p. 44). That indicates economic expansion and territorial acquisition has always been a problem promoted since the First World War. Even in the 1920s, it was fashionable to declare the German empire on the threshold of the ‘Great War’ (Keylor, 2001, p. 44).

Europe in the global context remained tense and divide...
8 Pages(2000 words)Article

Context Dependent Memory for Chewing Gum

“If a participant both learns and recalls information in the same environmental context, or state, then recall is generally superior compared to a condition where the learning and recall contexts are different” (Miles & Johnson, 2007). Studies conducted to prove aromatherapist claims “demonstrated that as long as the same odor was present at learning and at the recall of learned information, recall performance was improved when compared to conditions in which a different odor was present at learning and at recall; a no odor control group; or the odor was present at learning or retrieval only” (Cohn, 2002). According to Mead and Ball (2005), a number of different contexts can produce CDM effects on recal...
6 Pages(1500 words)Literature review

Using Self Efficacy to Increase Staff Performance

The methodology section of the paper makes use of the qualitative narrative storytelling approach and two separate interview sessions (one among the managers and the other among the selected employees) are employed as the primary research designs for the purpose of the study. The major themes derived out of the interviews are elaborately discussed and analyzed in Chapter 4. The conclusions of the study show that there exists an interrelated relationship between the self-efficacy of the staff and the leadership approaches of the managers or employers. The better the effectiveness of the leadership, the greater is the productivity of the workforce in an organization. The factors that contribute to the growth and development of the w...
37 Pages(9250 words)Thesis

Microprocessor System and Application

In a computer, a processor commonly involves one or more microprocessors (also acknowledged as chips), which are silvers of silicon or other substance stamped with many little electronic circuits. To perform operations on data, the computer passes electricity all the way through circuits to execute an instruction (Norton 2001.p. 5). The innovation in technology has brought a lot of facilities for us. We have better ways of life and all the facilities regarding better production and domestic tasks. Such as in the industrial production we have automatic robots that are welding, packing, moving and carrying out several other development-related tasks. These robots are pre-programmed and microprocessors based chips are controlling all...
6 Pages(1500 words)Assignment

Structure of the Educational System in Morocco and Its Capacity for Addressing the Needs of the Hospitality Industry

... insights (Ministry of Tourism, Government of Morocco, 2009, “Key Figures” and “Observatory of Tourism”). It is important to understand that publications related to a detailed analysis of the quality and capacity of the education system in Morocco to cater for the requirements of the 2010 Vision for the country are scarce. Thus, it was necessary to use lateral thinking and comparisons to gain insights about the challenge for workforce training and development for the hospitality and tourism sector in Morocco. However, detailed information about the education system in Morocco is available, together with publications about skills requirements for hospitality and tourism occupations, capacity building for education and quality enhancement...
15 Pages(3750 words)Research Proposal

The Interprofessional Practice and the Health Care System

This is also the position Stone (2007) takes in the quote under discussion.
Furthermore, Stone goes on to declare that Australia has been very slow to implement this practice as compared with other countries and government agencies. One of the primary reasons is that the public policy system in Australia is quite complex and the decision-makers have not come into agreement on where to place it in the policy matrix. This leaves Interprofessional Practice and Education in the dark (or the cold) as far as strategic planning for implementation as well as placing itself within the funding cycles of the government disbursements. (Stone, 2007)
Policies are created in order to put in place how politicians and government official...
6 Pages(1500 words)Assignment

Evaluation of Performance of a Bank Using Published Accounting Data

...Table of Content Introduction: 2 Background 3 Thesis ment 4 Main Body 4 Conclusion 6 Limitations 7 Recommendations 7 Bibliography 8 Evaluation of Performance of a Bank Using Published Accounting Data Introduction: Banks are the global industrial powerhouses1 and they have introduced very complex and risky products and services. During its operation, every bank is exposed to credit risk, liquidity problems, interest risk, market risk, operational and management risk.2 The collapse of banking industry severely influences the world financial system, which means that it is very important to evaluate the performance of the banks. There are different parameters based on which performance of a bank can be evaluated such as financial management...
7 Pages(1750 words)Case Study

Using Computers to Teach Mathematics is Better than Traditional Methods

During the last two decades, huge advances in computer technology for information and communication purposes have impacted all levels of education and many courses as well. Using technology to support the teaching of Mathematics generally started later than for other subjects. The first electronic machine used to assist in calculation however was not the computer but the calculator. In schools in the US, UK and some other countries, the calculator has been used since the early 1980s. Incidentally, before electronic calculators, there were mechanical calculators and even before that the slide rule to aid calculation. In US schools, for example, the calculator was used by students between the fourth and eighth grades although its ac...
7 Pages(1750 words)Case Study

Identification of problems in the Criminal Justice System of the US

They are on trial and will be dealt with fairly. These laws ensure that no one, even if he or she has committed a crime is abused or punished cruelly.
Following the history of civilization like in china, we see the traces of systems for Criminal justice in order to provide safety for the citizens. Evolving through the years laws have been modified and changed to form the system that we know today.
 From its start, the “U.S. criminal justice system” has advocated the idea of “checks and balances”. To avoid dictatorial rule, the people who founded this system in such a way that one person was not given control or authority completely to punish the criminals. The idea of assigning a ‘jury...
6 Pages(1500 words)Assignment
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.

Let us find you another Dissertation on topic Oral Controlled Release System of Propranolol Using Gellan Gum Macrobeads with Magnesium Aluminum Silicate (veegum) for FREE!

Contact Us