Contact Us
Sign In / Sign Up for FREE
Go to advanced search...

Molecular regulation of actin dynamics in breast cancer - Essay Example

Comments (0) Cite this document
Subject: Health Sciences and Medicine, Essay   Topic Title: Molecular Regulation of Actin Dynamics in Breast Cancer. Date: 17th December 2012 Abstract Breast cancer is diagnosed in women worldwide and is a leading cause of breast-related mortality. Cancer cells migration is an essential stage of breast cancer metastasis…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER97.4% of users find it useful
Molecular regulation of actin dynamics in breast cancer
Read TextPreview

Extract of sample "Molecular regulation of actin dynamics in breast cancer"

Download file to see previous pages Actin, a prominent protein in the cytoskeleton is highly expressed in the nucleus of normal and cancerous cells and its regulation is an important molecular event in the progression of cancer where it plays crucial roles in the cell motility and migration. It is associated in protein-protein interaction. Actin-binding proteins (ABP) are involved in the molecular regulation of actin structure and dynamics where they modulate the nucleation of new actin filament. Consequently, the activities of ABP are regulated by various signaling pathways so that there is an appropriate spatial and temporal regulation of actin dynamics in cells. The Rho-family GTPases are the most explored actin binding protein and they include RhoA which modulates the formation of contractile stress fibers. The Rac1 activates the formation of lamellipodial actin filament network at the leading edge in motile cells. Membrane phophoinositides are also involved in the regulation of actin dynamics. These molecules associate with actin binding protein ultimately regulating the activity of actin. Metastasis plays a prominent role in the pathogenesis of cancer and identification of the mechanism influencing this metastasis is essential in the development of appropriate breast cancer treatment procedures. Metastasis is a complex process encompassing different steps such as neurovascularization, stromal invasion and infiltration of cancer cells into vascular and lymphatic spaces. Introduction Breast cancer is diagnosed in women all over the world and breast cancer metastasis is a leading cause of breast-related mortality in over 90% of cancer patients’ population (Ferlay et al., 2007). Motility of cancer cells is essential in the initial stage of breast cancer metastasis. Identifying the factors facilitating this motility is essential in establishing the contributing factors towards cancer invasion and metastasis. The eukaryotic cell is made of a filamentous network of microfilaments, intermediate filaments and microtubules. This structure is collectively referred to as the cytoskeleton. The cytoplasmic network has long been associated with cell motility and proliferation but studies have shown that actin, a prominent protein in the cytoskeleton is also highly expressed in the nucleus of normal and cancerous cells (Jockusch et al., 2006). Actin cytoskeleton regulation is an important molecular event in the progression of cancer and it plays crucial roles in the cell motility and migration. Among the abundant proteins in eukaryotic cell, actin is the most abundant (Dominguez and Holmes, 2011). This protein is involved in maintaining the complex internal infrastructure of eukaryotic cells. The internal infrastructure of the cell comprises the maintenance of shape and integrity which is associated with cellular functioning. This protein forms a tangle of cross-linked filaments referred to as actin cytoskeleton that provides the organizational scaffold of animal, plant and fungal cells. In a typical cell organization, actin filaments are involved in the complex strenuous, structural tasks for instance, in the movement of myosin in muscle cells. The actin protein stricture encompasses a combination of strength and sensitivity. The actin structure can be termed as “dynamic” in virtue of their formation and roles. The dynamic model of actin is powered by a molecule of ATP which is bound to each actin monomer. Free actin bound to an ATP molecule, binds firmly to a ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
(“Molecular regulation of actin dynamics in breast cancer Essay”, n.d.)
Molecular regulation of actin dynamics in breast cancer Essay. Retrieved from
(Molecular Regulation of Actin Dynamics in Breast Cancer Essay)
Molecular Regulation of Actin Dynamics in Breast Cancer Essay.
“Molecular Regulation of Actin Dynamics in Breast Cancer Essay”, n.d.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document

CHECK THESE SAMPLES OF Molecular regulation of actin dynamics in breast cancer

Breast Cancer

.... Natl. Cancer Inst. 100 (4): 228–9. doi:10.1093/jnci/djn013. PMID 18270336. Boughey JC, Wagner J, Garrett BJ, et al (March 2009). "Neoadjuvant Chemotherapy in Invasive Lobular Carcinoma May Not Improve Rates of Breast Conservation". Ann. Surg. Oncol. 16 (6): 1606–11. doi:10.1245/s10434-009-0402-z. PMID 19280264. Gonzalez-Angulo AM, Morales-Vasquez F, Hortobagyi GN (2007). "Overview of resistance to systemic therapy in patients with breast cancer". Adv. Exp. Med. Biol. 608: 1–22. doi:10.1007/978-0-387-74039-3_1. PMID 17993229. Kumar V, Abbas AK, Fausto N, Mitchell R (2007), Robbins Basic Pathology, 8th edition, Chapter 19 - The Female Genital System and...
9 Pages(2250 words)Research Paper

Breast Cancer

...the diagnosis of a breast cancer based on the results of a biopsy ordered on the patient (British Medical Association, 2008). Pathophysiology. Pathophysiology is “the study of the disease on body functions” (British Medical Association, 2008, p. 436). The current knowledge on the pathophysiology of breast cancers is that the condition emerges after a series of molecular changes at the cellular level that result in the “outgrowth and spread of breast ephithelial cells with immortal features and uncontrolled growth” (Swart, 2011, second paragraph). Genome studies indicated discrete tumor subtypes with distinct characteristics (Swart,...
5 Pages(1250 words)Essay

Breast Cancer

...targeting the breast cancer at molecular levels are under study to provide as a better treatment option. Furthermore the role of BAG-1, a protein which is considered to cause chemotherapeutic agents resistance, is also studied in the causation of breast cancer. The over-expression of BAG-1 observed in tissue biopsies is important in deciding treatment strategies (Yao 2006). Breast cancer is an important malignancy in women because of its high incidence. The signs and symptoms of breast cancer are important to be understood by women as the early detection of the tumor plays an important...
5 Pages(1250 words)Essay

Breast Cancer

...?Introduction Breast cancer is one of the most common cancers worldwide at present and is the leading cause of death among women (Johnston et al, 2008). Breast cancer is classified into three major groups as follows: 1) operable breast cancer, 2) locally advanced breast cancer and, 3) metastatic breast cancer (Johnston et al, 2008). Operable breast cancer is characterized by the presence of malignant cells within the milk ducts and other regions of the breast, which sometimes may include the local lymph nodes. The lumps or growths can be removed surgically provided that at the time of operation the patient does not have overt metastases. Locally advanced breast cancer is distinguished by the application of the TNM Staging Process... and is...
5 Pages(1250 words)Research Paper

ESBL positive Escherichia coli and Klebsiella interaction with human urothelial cells

...and and hidradenitis suppurativa. Other dermatologic problems treated are psoriasis vulgaris, localized scleroderma, disseminated actinic porokeratosis (DSAP), cutaneous T-cell lymphoma (CTCL), and vulval lichen sclerosus (LS). Nondermatologic applications of PDT are anal and vulvar carcinoma, macular degeneration of the retina, spread of metastatic breast cancer to skin, and Barrett’s esophagus. The field of antimicrobials that is seen to benefit most from photodynamic therapy is the control of bacterial diseases originating from extended-spectrum ?-lactamase producing bacteria. The range and degree of the effects of these infective bacteria, and the array of antibiotics that they are...
22 Pages(5500 words)Literature review

Breast Cancer

...? Public Health & Breast Cancer A Report on Breast Cancer as a Public Health Issue School Introduction Public health is an important aspectof the population’s wellness, wellbeing and health. Public health aims to educate and provide a population with the tools that they need to manage and prevent diseases and to promote sanitary behaviours such as hand washing. Public health objectives can range from targeting fairly benign diseases such as the common cold, to life-threatening and devastating types of cancer. Health itself is defined by the World Health Organization as being a “state of complete physical, mental and social well-being and not merely the...
6 Pages(1500 words)Research Paper

Breast Cancer

...the ailment as well as the extent of anticipations along with awareness. Moreover, administering analgesics as per requirement, relieving anxiety and relaxing the patient, giving skin care to the affected areas, keeping a close vigil upon treatment related complexities such as vomiting and bleeding among others are crucial factors (American Cancer Society, 2012). Short-term Goals Short-term goals entail: Proper breast screening To educate the community Perform regular exercise Making proper assessment Long-term Goals Long-term goals include: To introduce strict rules and regulations regarding the abuse of alcohol To educate the people especially women regarding the impact of smoking...
3 Pages(750 words)Admission/Application Essay

Breast cancer

...?Running Head: Breast Cancer Breast Cancer [Institute’s Table of Contents Table of Contents 2 INTRODUCTION 3 STAGES & TYPES 4 RISK FACTORS 5 DIAGNOSIS & TREATMENT 6 CONCLUSION 7 REFERENCES 8 INTRODUCTION Since few years, cancer has become one of the most perilous diseases that have resulted in death of millions of people worldwide. There are many types of cancer. As the name indicates, cancer cells are produced in the breast part with the possibility of affecting other organs and tissues of the human body. Cells are the basic elements that create tissues in the body. Research (McPhee & Tierney, 2007, pp....
4 Pages(1000 words)Essay

Breast Cancer

...Breast Cancer: Research Proposal Introduction Transcription, in its simplest conceptualization is the synthesis of Ribonucleic Acid (RNA) from a DNAtemplate (McClean, 1998). Whether it is prokaryotic or eukaryotic, it first undergoes the process of initiation where there is a binding of RNA polymerase to double-strand DNA; then the second process follows called elongation where there is a development of a short stretch of DNA which is mostly of a single-strand (McClean, 1998); the last stage is the termination stage where there is a recognition of the transcription termination sequence (McClean, 1998). The RNA polymerase needs other proteins in order to carry out the transcription process. Ensuring...
5 Pages(1250 words)Essay

Breast Cancer

...Global Prevalence of Breast Cancer affiliation Introduction Breast Cancer refers to the cancerous cells thatform around the breast. It is a common cancer diagnosis in women especially in United States. However, it can occur in both men and women. It is a malignant tumor in the breast. Malignant tumor is part of a group of cancer cells that grow in the surrounding tissues and spreads to distant areas in the body. Most of it starts in the cells of the ducts and others in lobules and others in some tissues. These cells in the breast are abnormal and they usually multiply...
6 Pages(1500 words)Research Paper
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.

Let us find you another Essay on topic Molecular regulation of actin dynamics in breast cancer for FREE!

Contact Us