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Clinical biochemistry - Assignment Example

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The main co-factor is magnesium ion. On the other hand, substrates of COMT generally include any compound with a catechol structure such as catechol-containing flavanoids and catechoestrogens. Other substrates for the enzyme include epicatechin + S-adenosyl-L-methionine, epigallocatechin-3-O-gallate + S-adenosyl-L-methionine and (R)-1,2-dihydroxy-4-[2-(methylamino)butyl]benzene + S-adenosyl-L-methionine. A patient with mutations(single nucleotide polymorphism that eliminates or reduces the function of Catechol-O-methyltransferase is likely to suffer from a wide range of difficulties including panic disorder, paranoid schizophrenia among other related conditions due to the impaired regulation of catecholamines (Golan 210).   MAO (Monoamine oxidase) Monoamine oxidase is a group of enzymes that functions by catalyzing the oxidative deamination of monomines. In humans, the enzymes occur in two major types namely, MAO-A and MAO-B both of which are commonly found in the astroglia and neurons as well as outside the central nervous system. They are normally classified as flavoproteins due to the fact that they contain covalently bonded cofactor FAD. MAO itself is considered to be a substrate for most monoamine oxidase drugs (Edmondson 86). The common substrates for the enzyme include monoamines in the ingested food (MAO-A), monoaminergic neurotransmitters, tyramine and dopamine. Specific substrates for MAO-A include Melatonin, adrenaline, Serotonin and noradrenaline while MAO-B usually breaks down

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Clinical Biochemistry Assignment Other name (s) Course Clinical Biochemistry Assignment Enzymes COMT (Catechol-O-methyltransferase) COMT (Catechol-O-methyltransferase) is an important enzyme that acts as a catalyst in the transfer of methyl group from S-adenosylmethione to catecholamines including epineprhrine, neurotrsnmitters, dopamine and nonepineprhrine (BRENDA 2)…
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