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Based on the first statement, “Starvation causes a cellular response…that encodes…hsp70 and hsp60 family members,” and the second statement, “Starvation can diminish some of the signs of aging,” it seems that there is a link between the encoding of hsp70 and hsp60…
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Download file to see previous pages nserved proteins responsible for the maintenance of the conformational homeostasis of cellular proteins and RNAs” and are believed to be usually induced by environmental stress (Soti & Csermely, “Molecular Chaperones” 227). In short, as molecular chaperones are often associated with aging tissues and aging in general, these proteins are especially found in such situations. There is, however, a debate whether their presence in the aging tissue is merely induced or it is this presence that induces aging. Hsp60 is involved in protein folding and hsp70 has a role in the regulating the heat shock response as well as membrane translocation. While hsp60 are found in the mitochondria, hsp70 is found in the eukaryotic cytosol, ER and mitochondria. Both families of proteins actually function for protein translocation and transport as well as folding and assembly (“Molecular Chaperones”). In aging and diseased tissues, high amounts of hsp60 are found in people with atherosclerosis, acute coronary syndromes and angina, while hsp70 is found in those with peripheral as well as renal vascular diseases (Frostegard & Pockley 201-202).
A number of experts and experiments in the field of molecular biology are pointing out that chaperones are the ones that bring about the aging process at the molecular level. Soti and Csermely, in their study entitled “Chaperones and aging: role in neurodegeneration and in other civilizational diseases, underlined the possibility that HSPs “might contribute to the onset of…atherosclerosis, cancer, diabetes and several neurodegenerative diseases” (384). In an actual experimental study in Korea, it was confirmed that the HSPs “might be involved in tumorigenesis” as it did in patients with hepatocellular carcinomas (Lim et al. 2077). This is so because, as proven by rodent experiments, “HSPs are known to be essential for the survival of cancer cells in different cancers” (Lim et al. 2077). Moreover, one particular HSP, hsp90, ...Download file to see next pagesRead More
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