Ileal-Lymphoid-Nodular Hyperplasia, Non-Specific Colitis, and Pervasive Developmental Disorder in Children - Assignment Example

The children also complained of abdominal pain and diarrhea. Conducted to an average mean age of six, the children underwent gastrointestinal, developmental tests, and neurological testing. The results show that all the children had the gastrointestinal disease and poor development. The poor development is associated with the change of environment from their homes to the pediatric facility (A J Walkfield, 1998).

Method

The method of testing includes clinical investigation, laboratory investigation, and histology. Developmental testing is conducted with the help of the parents. Ileocolonoscopy is then conducted after bowel preparation. Biopsy samples of the mucosa are then taken for testing from the terminal ileum. Urine is also tested to measure the amount of urinary methylmalonic acid. Magnetic imaging resonance is conducted to check the cerebral response. Stem auditory and sensory together with a lumbar puncture is also done.

Results

None of the 12 children showed neurological abnormalities according to the clinical tests. Child number eight showed slow development because of an earlier operation on her aorta. Eight of the children showed poor development due to infection of measles, mumps, or rubella vaccination. All the children tested negative for antiendomyseal test. Eight children were reported to have mucosal and rectal abnormalities. Terminal lymphoid hyperplasia was also reported in nine children. Parasites and organisms were not present in the intestines of the 12 children. The goblet cells were not also depleted.

Discussion

The developmental regression results from loss of coordination in the bladder or bowel function. The increased permeability into the intestinal walls is a result of a deficiency of the phenyl-sulfur transferase enzyme. Strains of measles vaccine have been traced to children suffering from autoimmune hepatitis hence playing a major role in the developmental regression. Vitamin B12 was deficient in the children since there was an increase in the methylmalonic acid concentrations. Vitamin B12 is responsible for the formation of grey matter and myelin sheath, which are found in the central nervous system. A deficiency of the vitamin had a big role in nervous breakdown hence the regression in development. Autistic disorders also result from excessive absorption of gut-derived peptides and incomplete breakdown of food. Autistic disorder is mostly associated with boys as compared to girls and is most likely to be a gene disorder transferred from one generation to another.

Conclusion

The study conducted together with experimental tests conducted on the children showed that gastrointestinal disorders have a direct correlation with the development of children. Low concentrations of alpha one antitrypsin in children resulted in abnormal permeability within the intestine (Walker Smith, 2002). Lack of peptidase enzyme required for opioids a substance that helps in endogenous break down of the central nervous system also results in regression in development.