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Bispecific Antibodies: production and use - Essay Example

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Bispecific antibody is an artificial protein comprising fragments of two distinct monoclonal antibodies, and subsequently binds to two dissimilar kinds of antigen. This antibody if widely applied in cancer immunotherapy, where bispecific antibody is engineered to bind simultaneously to a cytotoxic cell (CD3) and tumor cell (target). …
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Bispecific Antibodies: production and use
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Download file to see previous pages A bispecific antibody put against EGFR and MET (receptor tyrosine) mono-valently binds the targets, suppresses EGFR and MET driven tumor and cell growth, as well as inhibits their signaling. Such production strategy enables rapid bispecific antibody generation from any two antibodies in existence and yields varying quantities of bispecific antibodies adequate for a broad range of preclinical and discovery applications (FLICKINGER, 2013). Bispecific antibody is widely acknowledged and recognized as therapeutic molecules. This is due to the four approvals outside the United States and 23 approvals in the United States and other countries. The success of therapy and commercial resulting from bispecific antibodies inspires antibody producers and engineers to enhance the effectiveness of bispecific molecules. Subsequently, a new wave of antibodies is being evaluated in clinics, expecting various approvals. Such antibodies have been engineered with Fc leading to higher effector roles such as cytoxicity depending on complement and cell mediated cytoxicity depending on antibody (PAUL, 2008).
Additionally, studies on various classes of bispecific antibodies, antibody therapeutics has led to remarkable clinical results, and the first bispecific antibody catumaxomab approval. For example a T cell retargeting agent approved in April 2009 in the European Union. Studies have also focused on recent clinical study and advances results about bispecific antibodies....
tionally, studies on various classes of bispecific antibodies, antibody therapeutics has led to remarkable clinical results, and the first bispecific antibody catumaxomab approval. For example a T cell retargeting agent approved in April 2009 in the European Union. Studies have also focused on recent clinical study and advances results about bispecific antibodies. Such studies are geared towards producing a new class of molecules to outshine bispecific antibodies as cancer immune therapy in the future. Bispecific antibodies possess a higher potential of cytotoxic. The antibodies bind to antigens that are weakly expressed. T-lymphocytes are not activated by cancer immunotherapy with bispecific antibodies because they do not have Fc receptors. This means the Fc region is not able to bind to them, while the Fab regions are used for tumor cells binding (PAUL, 2008). The production and design of bispecific antibodies is not easy. Production of bispecific antibodies has remained a challenge to most molecule engineers (ALFERMANN & VERPOORTE, 2000). This is because of the need to integrate two different light and heavy chain pairs, and at the same time keep and maintain the architecture of the natural non-immunogenic antibody. Today, bispecific antibody is acknowledged and recognized as therapeutic molecules. This is because of the worldwide approvals: four approvals outside the United States and 23 approvals in the United States and other countries. Engineers of bispecific antibodies and bispecific antibody producers have been inspired by the success of therapy and commercial that result from bispecific antibodies to continually enhance and promote the effectiveness of bispecific molecules (FLICKINGER, 2013). This paper seeks to discuss bispecific antibodies, their ...Download file to see next pagesRead More
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