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Genetic reprogramming holds great promise for the discipline of regenerative medicine, because of the ability to obtain patient- - Research Paper Example

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Name Institution Course Instructor Date Regenerative Medicine Introduction Regenerative medicine involves the regenerating human cells and tissues to replace damaged ones. This field of medicine aims at accelerating the healing of damaged tissues and organs…
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Genetic reprogramming holds great promise for the discipline of regenerative medicine, because of the ability to obtain patient-
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Download file to see previous pages These cells are similar to embryonic cells in that they can differentiate into the various body cells under favorable conditions. The advantage of iPSCs cells over the embryonic cells is that they do not need embryos during production. This makes the technology ethically acceptable. IPSCs cells production involves inserting of stem cell associated genes into specialized somatic cells using viral vectors (Xiong et al 1). Genetic engineers hopefully believe iPSCs cells will initiate the production of cells or tissue from a patient that will repair the damaged tissues. The cells regenerated through induced pluripotent stem cell method are most suitable in restoring damaged cells and tissues. This is because the patient’s immune system will readily tolerate them. This will eliminate the problem of graft rejection exhibited in xenografts or isografts. Elimination of immune suppressive drugs on patients usually does happen. Despite all these seemingly possible setbacks, induced pluripotent stem cells have proofed to be the future of the regenerative medicine. Patients suffering from cardiovascular disease and other disorders will find cure after the establishment of this technology. Application of iPSCs in treatment of cardiovascular disease Cardiovascular disease affects the cardiovascular system (the heart and the blood vessels). These diseases include coronary heart disease, stroke, congestive heart failure, pulmonary embolism among others. The iPSCs technology promises a positive break through to the medicine world (Amit &Joseph112). The ability to induce adult specific cells into stem cell without use of embryo enables clinicians to change other cells from a patient. The body recognizes the cells as self and therefore no rejection can occur. Researchers are successfully modeling many cardiovascular diseases by this technology. The improved understanding of the cardiovascular diseases provides a better treatment in the medicine world. Formation of cardiomyocytes Reprogramming of somatic cells into iPSCs is by integrating or non-integrating method. The integrating method uses viral vector while the non-integrating method uses a plasmid to deliver the genes. For cardiovascular disease treatment, the most suitable is the non-integrating method. Reprogramming of the fibroblasts of the dermis of the patient produces the iPSCs for use. A method called embroyoid body differentiation turns the iPSCs to revolve into cardiomyocytes (Nelson et al 2). The cardiac cells produced this way show the same characteristics of human cardiac cells although they may differ in morphology. To determine functionality of the iPSCs, cardiomyocytes researchers use molecular techniques such as immunocytochemistry and polymerase chain reaction techniques (Amit & Joseph117). The cardiomyocytes formed from patient cells posses the mutations that cause disease in the patient. These cells serve as the model for the disease and therefore further investigations are possible. Modeling of inherited cardiovascular diseases is very important in determining its cure. The iPSCs cardiomyocytes (heart muscle cells) provide the best model for these diseases. The iPSCs provide insights to concerns of heart repair. This technology is a potential source of cells for repairing the heart and blood vessels. Studies done by Li and co-researchers gave the evidence that induced pluripotent stem cells would provide unlimited resources for transplantation. This form of tissue ...Download file to see next pagesRead More
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