Nobody downloaded yet

The role of procoagulant microparticles in haemostasis - Essay Example

Comments (0) Cite this document
Summary
The role of procoagulant microparticles in hemostasis Name Institution Tutor Date The role of procoagulant microparticles in hemostasis Healthy individuals contain microparticles (MPs), which increase with the occurrence of various diseases such as CVD, cancer, and diabetes…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER95.9% of users find it useful
The role of procoagulant microparticles in haemostasis
Read TextPreview

Extract of sample "The role of procoagulant microparticles in haemostasis"

Download file to see previous pages Procoagulant MPs mostly appear as a result of apoptosis and vascular cell activation. An increase in the level of monocyte, platelet, or endothelial-derived MPs circulating in the blood is associated with CVD risk factors and indicates poor clinical outcome. They indicate vascular cell damage and interfere with atherothrombosis by exerting effects on vascular and blood cells. Under disease conditions, cellular cross-talk is supported by circulating MPs support, which leads to vascular inflammation, leukocyte adhesion, endothelial dysfunction, and stimulation. Functional tissue factor and exposed membrane phosphatidyserine are procoagulant entities produced by circulating MPs. Platelet derived MPs (PMPs) contain anionic phospholipid PS, which makes them strongly procoagulant. The removal of MPs from the blood of normal human plasma prolongs the clotting time (Ahn, 2005). Platelet derived MPs support thrombin generation in plasma without platelets, which are important for blood clotting. Platelets form an important substrate for coagulation and their membranes provide a surface for the formation of prothrombinase complex. This enzyme is utilized in the conversion of fibrinogen to fibrin which combines with other factors to form a stable clot (Lawrie et al, 2009). The availability of platelet MPs at the site of vessel injury contributes to the clotting process by providing a large surface membrane necessary for enzymatic process. The exposure of phosphotidyserine during thrombin generation increases enzymatic catalytic effect. The large surface formed by MPs is necessary for activating the coagulation cascade that forms the fibrin clot. Circulating MPs harbor cytoplasmic effectors or functional membrane that promotes prothrombotic responses (Ay et al, 2009). These MPs channel their procoagulant potential to the target in the presence of the appropriate counter ligands. They bind onto soluble immobilized fibrinogen forming aggregates that enhance the delivery of procoagulant entities. In vitro, TF and TF-dependent procoagulant mechanism is facilitated by the interaction of monocytes and endothelial MPs. TF is a constituent protein in minute amounts that flips the endothelial procoagulant properties resulting in the initiation of a TF-driven clotting process. Blood-borne TF can be incorporated in the developing thrombus through a series of TF-dependent, CD15 and CD18, and interactions. Blood-borne TF is mainly harbored by PMPs and monocyte-derived MPs provide the enzyme after lipopolysaccharide stimulation. Polunuclear leukocytes and endothelial-derived MPs also produce blood-borne TF under drastic endothelial activation. These MPs provide the required amount of TF and circulate the enzyme, which is necessary for maintaining a hemostatic balance. MPs, selectins and TF merge into an important triad of thrombosis. The surfaces of platelet and endothelial cells contain an important adhesion molecule called P-selectin (Hugel et al, 2005). The molecule is utilized during TF accumulation and leukocyte inclusion in the thrombus when an endothelial injury occurs. The accumulation of hematopeic cell-derived TF is similar to the MPs accumulation kinetics before leukocyte-thrombus interaction. A soluble P-selectin enhances the production of leukocyte-derived TF-MPs used to correct hemostasis. The plasma levels of microparticles increase with age, which indicates the contribution of P-selectin pathway. P-selectin pathway also favors the transfer of PF into monocyte derived ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
  • CHICAGO
(“The role of procoagulant microparticles in haemostasis Essay”, n.d.)
Retrieved from https://studentshare.org/biology/1466662-the-role-of-procoagulant-microparticles-in
(The Role of Procoagulant Microparticles in Haemostasis Essay)
https://studentshare.org/biology/1466662-the-role-of-procoagulant-microparticles-in.
“The Role of Procoagulant Microparticles in Haemostasis Essay”, n.d. https://studentshare.org/biology/1466662-the-role-of-procoagulant-microparticles-in.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document

CHECK THESE SAMPLES OF The role of procoagulant microparticles in haemostasis

NURSNG ROLE

...? Nursing Role This paper lays out the outline of the nursing role. The introduction brings into perspective the growth that the nursing profession has experienced and the challenges that led to such leaps in the society. It further focuses on the relationship change between the doctor or physician and the nurses over time. The nursing profession encompasses many specializations. In order to understand the outlined roles, the various specializations must come to focus. This outline, therefore, elucidates the specific divisions and specializations of the nursing profession and the relevant duties to those specializations. The outline also focuses on the two main roles of...
6 Pages(1500 words)Research Paper

Nurses role

...? Nurses role The study of this research is aimed at exploring the role of nurses in prevention of the healthcare associated infections. Theconcept of healthcare associated infections has been defined in this research. The characteristics of healthcare associated infections have been studied. The essential conditions that lead to the transmission of healthcare associated infections to susceptible patients are identified in the research process. The various features of healthcare associated infections that distinguish it from other diseases have been studied in the research process. The nurses have been identified as the frontline people for prevention of health care associated infections. The duties and...
4 Pages(1000 words)Research Paper

Disease processes

...will be prolonged. 2. Why is this test effective for monitoring oral anticoagulant therapy Prothrombin test is most common to use for monitoring in oral anticoagulant therapy Warfarin and related coumarins. The PT responds to reduction of three of the four vitamin K-dependent procoagulant clotting factors (II, VII, and X). This PT test gauges the time or period of reaction of Plasma to Thromboplastin and Ca++ that results to Fibrin Clot. 3. What is the difference between reporting PT results as INR or Prothrombin Index Quick activity (PI%) The INR value is calculated from the patient's coagulation time. However, the ISI value is included in the calculation. The manufacturer calculates the ISI value...
2 Pages(500 words)Lab Report

Woman Role

...Through the ages the status of women in a patriarchal society has been subservient to men. The patriarchal society was created by men to maintain a dominant position in the society that restricts the role of women in any decision making and promotes a set of rules for their conduct and actions, both within the family and outside the family environment. The women are denied the basic right for self expression and empowerment of women has increasingly become a major issue for the societies at large. The article highlights the social status of Florentine women in Italian society which was marked by clear cut social and cultural expectations that were associated with the different genders. Cooking was considered to be the...
2 Pages(500 words)Essay

US Role

...US Role Affiliation: What role does the United s play on the Arab/Israeli conflict? Introduction United States has always be in support of Israeli since it was formed in 1948 and hence has been seen to always be siding with it and especially in the wake of the September 11 terrorist attack. American presidents have however tried to play a mediator’s role in the Arab/Israeli conflict but in vain. The conflict was as a result of Israeli taking land from several Arab countries in 1967 including the infamous Gaza strip that has been fought over by Hamas (Jhally and Ratzkoff 2004). The mediation role between the Arab nations and the Israeli started in 1973 with the camp David...
2 Pages(500 words)Essay

Haemostasis Disorders

... Haemostasis Disorders – Case Study 1 1. The testing was done because the patient showed symptoms, medical history, and family history of a genetic blood disorder, specifically one related to clotting. The patient reports extensive bruising, unusual nosebleeds, and a family history of similar symptoms. Testing Factor VIII-related antigens and Factor VIIIc is therefore indicated because of their connection to blood clotting disorders, especially haemophilia. Similarly, bleeding time, prothombin time, and APTT are used as indicators of the clotting tendency of the blood of the patient and can be used to detect any abnormalities. Since platelets are the cause of blood clotting, it also makes sense that platelet function...
5 Pages(1250 words)Essay

Role Reflection

...Role Reflection Reflection on the Article Curriculum development and implementation are important responsibilities of top administration of school. It is essential to make sure that appropriate measures are taken to monitor the implementation of curriculum. The article under discussion focuses on the role of principals monitoring curriculum implementation. The article identifies an ongoing problem in the schools regarding the implementation of curriculum and principals role in it. The problem is that principals do not ensure proper implementation of curriculum in schools. Money is invested in designing the right curriculum but proper measures are not taken to implement it. The article...
2 Pages(500 words)Essay

Alumni Role

...September 10, Alumni Role I have been fortunate to be accorded the opportunity to be accepted to an internship program with the Chinatown Public Health Center located at the City and County of San Francisco, Department of Public Health. Its complete address is at 1490 Mason Street San Francisco, CA 94133 and the name and title of the supervisor who I report to is Ms. Lei-Chun Fung, MPH, MSW, Health Educator. At the onset, I adapted to the facility and my supervisor began dispensing my services. The experience is a deemed as a continuous learning process where I imbibe the intricate details of the practice. I have worked assisting in various programs at the facility through promoting education in the following: the...
1 Pages(250 words)Essay

Role Models

...Role models Qualities of a good role model Summary of the article- The article is by Freddie Silver who proposes thatyoungsters benefit from having relations with people who are older and wiser who can mentor them. The author claims that effective role models have certain characteristics that make the identifiable as people to look up to. Role models inspire others to undertake changes and work towards newer goals. Main ideas: the author proposes the qualities of a good role model as the following; moral, confident, hardworking, respectful, optimistic, and creative. Useful quotes- “role models who support worthwhile causes and who are...
3 Pages(750 words)Essay

The Role

...as possible signalizes of the ability of the civic engagement to deal only with limited circle of social problems. In other words, there is a need of numerous civic organizations to appear in order to face numerous community problems. For instance, youth is commonly more active because of civic engagement popularity within higher education (Adler and Goggin, 2005, p. 245). In this context, Theiss-Morse and Hibbing (2005) determine the key role of already existing civic organization on the ability of civic engagement to have a significant influence on community problem solving (p. 228). Hence, not only group homogeneity but also the strength of established civic institutions enable the impact of civic engagement in...
3 Pages(750 words)Essay
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.

Let us find you another Essay on topic The role of procoagulant microparticles in haemostasis for FREE!

Contact Us