The Role of Oxidative Stress in Diabetic Retinopath - Dissertation Example

Comments (0) Cite this document
Summary
The Role of Oxidative Stress in Diabetic Retinopathy Contents 1. Introduction 3 2. Oxidative Stress in Diabetes 5 2.1 Development of Oxidative Stress 6 2.2 Measuring Oxidative Stress 7 3. Early Signs of Oxidative Stress 8 4. Diabetic Retinopathy 10 5. The Role of Oxidative Stress 11 5.1 Proliferative Diabetic Retinopathy 14 5.2 Alternative approaches 14 6…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER91.2% of users find it useful
The Role of Oxidative Stress in Diabetic Retinopath
Read TextPreview

Extract of sample "The Role of Oxidative Stress in Diabetic Retinopath"

Download file to see previous pages Insulin is an important component in the regulation of the glucose pathway in humans as well as some other animals. Because of this, the inability to effectively create or use insulin results in significant health problems, and also has the potential to create diabetic complications as the disease progresses (Hartnett et al. 2000). Diabetes dramatically increases the chance of obtaining either a vascular or a microvascular condition (Pennathur and Heinecke 2004). The first form of diabetes is type I, where individuals are unable to produce insulin. People with this form of diabetes make up approximately five to ten percent of the diabetic population. They are also known as insulin-dependent (IDDM), and the two terms can be used interchangeably. In contrast, the remainder of diabetes patients are able to produce insulin but do not have the correct cellular response to the hormone. This is known as type II diabetes. Individuals with this form of the disease are non-insulin-dependent (NIDDM). As diabetes progresses, a number of different complications can develop, including diabetic retinopathy, which results in permanent loss of vision due to tissue damage (Hartnett et al. 2000). ...
Because this occurs, the oxidative species are able to significantly damage the tissues of the body (Evans et al. 2003). It is argued that this is strongly related to the development of hyperglycemia (Cvetkovic et al. 2009). The development of complications has significant impact for people suffering from diabetes, resulting in significant decreases in quality of life, among other effects. One particularly strong effect of diabetic retinopathy is that at the current time it is incurable, meaning that people with this complication must life with its effects for the rest of their lives. Currently, diabetic retinopathy is one of the most common complications that occurs as the result of diabetes, and the majority or all suffers will end up with the complication after having diabetes for between 15 and 20 years (Bucolo et al. 2012). Because of the prevalence of diabetic retinopathy and its significant effects, it is crucial to understand the way that this complication develops, and whether these mechanisms are able to be used in the development of preventative or curative treatments for the disorder. As with other diabetic complications, oxidative stress is believed to play a crucial role in the development and maintenance of diabetic retinopathy. The aim of this paper is to examine recent research in the field of oxidative stress in diabetic retinopathy, and consider the strengths and weaknesses of current knowledge. It is hoped that the conclusions of this paper will help to inform future research and determine the gaps present in the research on this area. 2. Oxidative Stress in Diabetes Oxidative stress is the underlying factor in most mechanisms of diabetes (Neri ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
  • CHICAGO
(“The Role of Oxidative Stress in Diabetic Retinopath Dissertation”, n.d.)
The Role of Oxidative Stress in Diabetic Retinopath Dissertation. Retrieved from https://studentshare.org/biology/1399495-the-role-of-oxidative-stress-in-diabetic
(The Role of Oxidative Stress in Diabetic Retinopath Dissertation)
The Role of Oxidative Stress in Diabetic Retinopath Dissertation. https://studentshare.org/biology/1399495-the-role-of-oxidative-stress-in-diabetic.
“The Role of Oxidative Stress in Diabetic Retinopath Dissertation”, n.d. https://studentshare.org/biology/1399495-the-role-of-oxidative-stress-in-diabetic.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document

CHECK THESE SAMPLES OF The Role of Oxidative Stress in Diabetic Retinopath

Chronic Diabetic

...organs such as blood vessels and the heart, in the process exposing a person to heart attack, stroke and kidney problems. As mentioned earlier managing and preventing these diabetes-associated complications require regular exercise, stress management, a balanced, low-salt diet, prescription medications and modest alcohol consumption. Significantly, regular blood pressure checkup is highly recommended. Heart disease or cardiovascular disease is another condition associated with chronic diabetes. It attacks and damages the arteries and the veins of the heart. In fact, scientific evidence shows that hyperglycemia worsens heart disease and other related complications. High blood pressure...
10 Pages(2500 words)Research Paper

Diabetic patient

...which are triggered by the socio-economic and environmental factors. Today theorists and researchers believe that most of the diseases can be cured only by making an intervention in the behavioral patterns of the patients (Hayden, 2009). For instance, in order to cure diabetes nurses can play a significant role since they are specialized in altering the external environment of the infected individuals. Here the Neuman’s system model can be used because its primary focus is the system around patients. Diabetes has a very close association with the mental state of victims including their family background and hereditary characteristics which creates immense stress in them....
5 Pages(1250 words)Assignment

Diabetic food

... and lastly, excessive amounts of antagonists. Consensus is that the aetiology is a multifactorial interaction of environmental and genetic factors. Genetics For Type 1 diabetes, genetic susceptibility predispose to diabetes is around 40%. However, the majority of those who are genetically predisposed do not develop diabetes. Risks of developing diabetes when close relative has diabetes are 30% for identical twins, 5% for siblings and 6% for offspring. However, for Type 2 the genetic predisposition is stronger than Type 1. The concordance rate in monozygotic twins is almost 100%. Environment Immune response by environment could be viral, diet and stress. Viruses may initiate mediated damage to beta cells by direct destruction... and the...
10 Pages(2500 words)Essay

Diabetic Retinopathy

...Diabetic Retinopathy Current Trends Order No: 175720 No: of pages - 2 Premium - 6530 Retinopathy is a known micro vascular complication of diabetes and refers to disturbances in the retinal blood vessels, which ultimately may lead to visual impairment (Williams & Pickup, 1999).Diabetic Retinopathy is a disease that has a specific micro vascular complication that occurs in insulin dependent patients (type 1) and non-insulin patients (type 2) It is the leading cause for irreversible vision loss. It is a common disease that affects 2% of the total population. A person having this condition experiences dark spots, blurriness or strange blotches. The prevalence of diabetic...
3 Pages(750 words)Essay

Glutathione is important in the defence against oxidative stress-

...to the extent that these protective mechanisms are effective (Vergauwen et al., 2003, 1578). Protective agents include dietary constituents that range from the anti-oxidant vitamins and minerals to the food addictives that might facilitate the action of natural anti-oxidants. It is being caused by imbalance between the production of reactive oxygen and ability of biological system that detoxify the reactive intermediate. Fink (2009, 249) asserts that glutathione plays major roles in the defense against oxidative stress. It has a major impact in aging and worsening of many diseases such as cancer, heart attack, liver diseases, sickle cell...
2 Pages(500 words)Essay

Diabetic

...such as irritability. Male and female copes with diabetes differently explained by different hormones in their bodies’ example Oxytocin, cortisol and epinephrine play a crucial role while dealing with diabetes stress. Under stress pressure the three hormones raise a person’s blood pressure thus lowering their immune system effectiveness (Clarkson, 2008). Women produce more of these hormones than male which makes them more emotional. Men secrete hormone Oxytocin at smaller amounts than women when stressed which makes it easier to control diabetes. The highest populations with diabetes are the Indians and...
12 Pages(3000 words)Essay

Diabetic neuropathy

...in blood pressure after standing up (Tesfaye, 2009). Other symptoms like loss in weight and depression have been reported in some patients, but they are not as a result of neuropathy, but often go together with it. There are various types of diabetic neuropathies which usually have varied effects to its patients such as autonomic neuropathy that causes hypoglycemia unawareness and changes in bladder role, perspiration and sexual response in patients. Focal neuropathy causes an unexpected weakness of nerves resulting to muscle weakness. Proximal neuropathy results to pain in the leg muscles like the thighs causing a weakness in the legs and finally the peripheral neuropathy mainly results to pain in the...
2 Pages(500 words)Essay

Unit V AAssessment#3 Oxidative Stress

...Oxidative stress is defined as the injury caused to cells as a result of increased formation of reactive oxygen species (ROS) and or decreased antioxidant reserve. Reactive oxygen metabolites such as OH- , H2O2 and O2- are continuously produced in vivo as products of aerobic metabolism. If the free radicals are not neutralized by endogenous antioxidants, they may endanger cellular integrity by causing oxidative DNA damage, lipid peroxidation and enzymatic oxidation (Gurjar, Molina, & Ojha, 2010: p 190) . Exposure to particulate matter (PM ) that contains toxic substances on their surface induces the production f ROS and hence the oxidative ...
1 Pages(250 words)Essay

Chronic fatigue syndrome, mitochondrial dysregulation and oxidative stress

..., the role of mitochondria in the cells of the human body is to provide energy for the body that helps humans to do work. Once these regulatory processes are interfered with, the process of energy manufacturing is also affected: there may be less energy produced or more or imbalanced regarding the time that it is needed. It may be related to chronic fatigue syndrome in the sense that, it may be a causative agent. Lack of enough energy that the body needs is what makes one feel tired hence fatigued (Lalsh, 1993). Therefore, those having chronic fatigue syndrome are likely to have mitochondrial dysfunction. Oxidative stress can be described as the constant imbalance between the...
8 Pages(2000 words)Essay

The relationship between Oxidative Stress and Apoptosis in Plants

...Topic al Affiliation The relationship between Oxidative Stress and Apoptosis in Plants Tor, Y. S., Yazan, L. S., Foo, J. B., Wibowo, A., Ismail, N., Ismail, M., Yazan, L. S., Yeap, S. K. (June 05, 2015). Induction of apoptosis in MCF-7 cells via oxidative stress generation, mitochondria-dependent and caspase-independent pathway by ethyl acetate extract of Dillenia suffruticosa and its chemical profile. Plos One, 106.) The Articles main objective is to expound on how cell death is induced in a MC7-cells culture via different biological processes such as generating oxidative stress by using a Dillenia suffruticosa Ethyl Acetate extract....
2 Pages(500 words)Annotated Bibliography
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.

Let us find you another Dissertation on topic The Role of Oxidative Stress in Diabetic Retinopath for FREE!

Contact Us