Alzheimer’s Disease is a “progressive and irreversible brain disorder that is manifested in dementia, motor lesions, and behavioral deficits” (Welsh, 2006, p.88). In the United States, Alzheimer’s Disease affects nearly a tenth of the population above 65 years of age;…
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The relationship of neuropathological features of Alzheimer’s Disease to the emergence of cognitive deficits, is not fully understood currently. However, “the process that results in the accumulation of Aβ as amyloid triggers the complex pathological changes ultimately leading to cognitive impairments” (Sun, 2007, p.40), known as the ‘amyloid cascade’ hypothesis. Lichtien and Mohajeri (2008) state that the high morbidity, socioeconomic costs, and lack of specific treatments indicate the importance of research on Alzheimer’s Disease.
Evidence from Lichtien and Mohajeri’s (2008) research on the efficacy of anti-amyloid immunization strategies, indicates that they serve as effective protective mechanisms against Alzheimer’s Disease. However, the underlying mechanisms of action of therapeutic antibodies, particularly their impact on the complex amyloid β peptide (Aβ) metabolism and various Aβ equilibria present both on the internal and external sides of the central nervous system, are not fully clear as yet. Moreover, physiological Aβ metabolism is not fully understood because of inadequate analytical tools to characterize and quantify treatment effects. Further, biomedical research is aimed at developing predictable therapies minimizing the risk of adverse effects such as brain inflammation and/ or hemorrhage caused by anti- Aβ immunization protocols.
The researchers found that standard Enzyme Linked Immune Sorbant Assay (ELISA) protocols are inadequate in rational drug design, and there is a requirement for more complex analytical tools to be developed and applied. Tests ensuring greater reliability in the assessments of Aβ in free versus protein-bound form, as well as monomeric versus aggregated Aβ, will be key to identifying the mechanisms forming the basis for efficacy and safety of the
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(Developments of Research on Alzheimer'S Essay Example | Topics and Well Written Essays - 1000 Words)
“Developments of Research on Alzheimer'S Essay Example | Topics and Well Written Essays - 1000 Words”, n.d. https://studentshare.org/anthropology/1607658-developments-of-research-on-alzheimers.
It presently is affecting approximately 5.4 million people n this country and is estimated to effect more than twice that number by the year 2050.(Anderson, and Hoffmann) There is nothing more precious to most people than the memories of the lives they have lived, the people they have shared it with
This disease can remain undetected for years, as the initial ones, mainly some forgetfulness, are typical for older ages and do not raise a red flag at first. The signs aren't clear and apparent to people at first, and are sometimes even missed by clinicians.
This has resulted into gambling activities becoming popular among adolescents. In fact, the proportion of adolescents joining gambling activities has increased as compared with adults. However, only a few cases have been reported of adolescents seeking help from the effects of gambling.
Current scientific research is under away looking at the causes treatment and possible preventions. The Synapses of the brain are destroyed in the thinking areas of the brain. Research shows that such people have damaged brain cells, called tangles, and amyloid plaques or deposits between cells.
Alzheimer’s disease is a form of dementia. It is progressive and there are no available treatments for this disease as yet. Eventually, it can cause the death of the patient. It is mostly diagnosed among elderly individuals, starting from the age of 65 years, although it has been known to also manifest earlier.
Its symptoms include tremors or trembling of the limbs and face while at rest; muscle stiffness/rigidity; slowing of movements or motor actions (Bradykinesia); and impaired coordination or imbalance. Patients