Schizophrenia - Research Paper Example

Background In this article, the objective was to examine the impacts of using antipsychotic medication to treat individuals with early episode schizophrenia illness. Wu et al. (2005) unfold schizophrenia as a persistent, severe, poorly understood, and debilitating psychotic illness that undoubtedly involves several disorders. The stamp schizophrenia symptoms are psychotic indicators such as delusions and auditory hallucinations. Impaired disturbances or cognition in information handing is not a highly vivid schizophrenia symptom although it can be highly disturbing.

For the individuals suffering from schizophrenia, Wu et al. (2005) study has unfolded lower rates of marriage, employment, and independent lifestyle in comparison to the normal people. A neuroimaging statistics collected by Bola et al. (2011) has confirmed anatomical abnormalities that include ventricles enlargement and reduction in the volume of the brain in the medial chronological areas. These observations are of greater study interest than clinical use. The hippocampus is a cortical, minute, supposedly seahorse-shaped brain part curled within the temporal lobe medial edge.

Functionally, hippocampus is a limbic system part when processing of the emptions takes place. In the hippocampus, the episodic or declarative memories are formed (memories of events and facts). The Alzheimer diseases (the memory problem preeminent disease) usually affect this hippocampus. A study by Haraldsson et al. (2011) examined the children suffering from schizophrenia as well as their healthy controls and siblings. At the onset of the study, the average age was approximated to be 12 years.

The illness hippocampal volume was observed to be less in comparison to that of the siblings and controls and recorded a steady decrease over the 12 follow-up years, although this decrease was not at an increasing rate. For the children suffering from schizophrenia, antipsychotic medications were administered. From the study, Haraldsson et al. (2011) observed a high likelihood of hippocampal volume deficit because of the illness. Therefore, the volume deficit was not linked to utilization of antipsychotic prescription.

Additional interests have also evaluated the various connections with the brain as opposed to specifically examining one brain part. Indeed, the neuropsychology reveal impaired processing of information as a result of Schizophrenia. From medical researches, anatomic abnormalities are observed in limbic and neocortical regions network. Method Search Strategy In this study, the Cochrane Schizophrenia group record was examined together with references of the studies that were included. For more data, the authors of some relevant studies were contacted to provide with further statistics.

Criteria of selection Randomized experimental trials were included with numerous second-episode and first-episode acute schizophrenia gamut disorders linking the early antipsychotic medication treatment with psychosocial, milieu, or placebo treatment. Data collection and analysis Working individually, the records from 18 studies were critically assessed. Out of these records, six were observed to meet toe inclusion standards. When possible, the risk ratios were calculated as well as their degree of confidence at 95% for the weighted mean differences and dichotomous