Monte Carlo Generation of TG-43 Parameters for the New Oncura Thin Seed - Literature review Example

Monte Carlo generation of TG-43 parameters for the new Oncura thin seed Name Institution Instructor Subject Date Introduction Brachytherapy is the type of radiation therapy that finds its application in the treatment of cancer. It uses the energy from radiation to kill the cancer cells. This is commonly in the form of ionization energy as noted by Rivard (2007). This action is performed by a number of medics who would include the dosimetrist, oncologist and the radiation therapists. Radioactive materials are placed directly on the permanent implants whereas; the needles catheters may be used for partial implants as stipulated by Nag, Wang, Wu, Bauer, Chambers & Davidorf (2003). The imaging system may be used in the process. Permanent brachytherapy would involve using the needles that are fixed with radioactive seeds that would be placed in the tumor. In the action, the Onco seed has the seed of model 6711 that have been sterilized and may be used. Essentially, brachytherapy is the scenario where the seed is implanted permanently so as to aid in prostate cancer treatment as noted by Bolomey & Fred (2001). This uses minute seeds that emit radiations which are temporary and aid in eliminating the cancer cells that may be present. For this action to be possible, radioactive elements such as cesium 131 and pd103 are used (Knutsen, Hafslund, Monge, Valen, Muren, Rekstad, Krohn, & Dahl, 2003). They are utilised while they are in the small titanium seeds that take the shape of the rice. The effect of the radiation makes the cancer cells to limit their multiplication capacity hence making them to get extinct with time. In case of a tumour, a much higher radiation would be acted on it so as to inhibit its DNA from multiplying that makes the prostate cancer cells to diminish with time (Nath & Chen, 2007). The new this seed defines the structure that is made of an alloy of gold that enhances there is reproducibility of the seed with minimum problems that are related to the silastic. It takes a shape of the template of the COMS original geometry that would ensure that the seed are packed directly to a given plaque using the USC plaques (Gupta, 2007). Apparently, the Onco Seed occur in a permanent area of the interstitial at given points of the tumor. This finds their application as one of the primary technique used in treating tumours of after the excision that has been performed on the primary tumor (Astrahan, 2005). Additionally, the seeds find their application in treating the various cases of superficilious intrathoracic and intra-abdominal tumors. Some seed are termed as radiosensitive as they are localized unresectable. The effect of the Onco Seed would eventually treat the tumors that are residual as at the same time the modalities of the treatment process that involves the aspect of chemotherapy and the radiation from the external beam. TG43 protocol, how they are obtained In order to obtain the TG-43 dosimetry, the techniques of the Monte Carlo methods are employed. This occurs at the photons that exist at a low energy that exist in the brachytherapy having the form of (18125I and 9103 Pd) (X-5 Monte Carlo Team, 2003).This is achieved by measurement of the thermoluminescent LiF of the solid water dosimeters. The micro tubes were obtained via descriptive and experimental techniques so as to obtain the parameters that are associated with the TG-43 (Reniers, Vynckier, & Scalliet, 2001). In order to obtain the depth of the of the water and air curve dose, the experiment used the radio chromic film that were acted in the ionization chamber with the aid of the spectrometer using the x-rays as noted by Krintz, Hanson, Ibbott, & Followill (2003). This aids in the distribution of the radiation that were obtained in the strength of the air kerma as noted by Chan & Prestwich (2002). There is need to have the broadening so as to enhance the accommodation of the effect of the current that emanates from the beam. In order to obtain the TG -43 dosimetry, the use of the finer resolution which are spatial are utilised. They involve the use of parameters such as the dose radial functions, data from the anisotropy and the dose rate constants. In medical field, the protocol obtained follows the form (TG-43) that establishes the functioning of the brachytherapy that finds their application in the interstitial collaborative Working group (ICWG). The dosimetry parameters of the TG-43 occur as a property of the distance obtained from the seed and the polar angle, which are related to the various axes. This utilizes the aspect of the anisotropy that leads to the bilinear interpolation to the point where the voxels are located. The dose values which are obtained are divided by their initial parameters so as to improve the accuracy of the results that would be obtained. The resultant leads to the values of L(r, ) that has a relationship with the geometric centre. The results from the comparison of the two dose rates indicate that there was favourable dose function in relation to the geometry function. The dosimetry of the TG-43 seems to be consistent with the radionuclide that emanates from the brachytherapy that are commonly known. The limitations that emanate from this experiment is the uncertainties of the values that were obtained. The utilization of the TG-43 finds their commercial application in treatment process that has a permanent treatment process that acts on prostate brachytherapy. Presently, the use of the TG-43U1 utilizes a single dataset that uses the distribution of 1D and 2D dose rate. Apparently, the photon emitted from the low energy was believed to treat cancer and even the therapy of the eye plaque that were associated with the permanent implants of the lungs. The generation of the (2D) dose rate of the TG-43 is identified as the dose rate that is related to the P (ro, o) and the SK. The  takes the form of cGyh-1U-1 that is reduced to cm-2. The value of  is defined as . The nature of the dose constant would depend on the source model and the form of radionuclide that would have an effect in the experimental technique. When this conditions are adhered to, the dose of the TG-43 would have a reproduction that was anticipated and related to the Monte Carlo dose rates emanating from F(r,  ) and g(r) as noted by Dolan, Li & Williamson (2006). In a situation where there is a 1D anisotropic function, the factor of the TG-43 would be identical to the  having a radial distance that takes the form  that is relate from the ratio of the average weight and the angle of the solid weight over a given steradian space. Monte Carlo simulation This appears apparent in the small size of the brachytherapy seeds that are associated with the implantation of the interstitial by using the needles that have small diameter as noted by Taylor, Yegin & Rogers (2007). Cases of health issues may emanate from the utilization of needles that have a smaller diameter. Various models of the brachytheraphy seed exits and depend on their respective dosimetric parameters (Rivard et al., 2004). Additionally, Brachytherapy of model 6711 is the mostly renowned type of seed. This simulation attributes to the property of the radioactive sources that emanate from the radioactive materials such as the seed of 6711125I model. The needles have to be placed in the prostate. This will lead to a swelling that is referred to as the edema (Gupta, 2007). The surgical trauma is believed to be the cause of this swelling. When needles with small diameter are used, the effect of swelling would greatly be reduced. This calls for the design of the 9011 model that presumes a small diameter having a cross-sectional area that is relatively small. As noted by Hedtjärn, Carlsson, & Williamson (2000), Monte Carlo simulation simulates the two models namely the 9011125i and the 6711 (Bolomey & Fred, 2001). This tends to seed the validation of the standard values of the 9011. This has to be in tandem with the AAPM TG-43U11 principles. This was performed by placing the marker that was opaque to the radio wave and was silver in colour. A mixture of 2um silver bromide and iodide (Br5 125I2 were coated to the marker that was of 2.8 mm and a density of 10.5 g/cm3 (Williamson, 2000). The micrometer was used in measuring the radiographic values to ascertain the dimensions of the weld. This gives the end of the marker to have a value of0.05mm taking an angle of 45o. In order to maximize the weld strength, the inner volume was filled with Ar in the capsule of 4.54g/cm3 of Ti. In order to maintain a consistent dimension, the microscope and the micrometer were used in obtaining the measurements of the radiographic and physical values. This utilise the photons of 30kvp emanating from a unit which is an outward unit that has to suit the values ofV.E.2 of 2004 given the AAPM. The results of welding leads to spherical shapes of the Ti liquids The simulations procedures utilised the code emanating from the transportation radiation. This occurred as a result of the photo atomic cross-section that relies on EPDL97 (Kawrakow, 2006). This was facilitated by use of techniques such as the sampling of resolution, derivation of the in vacuum, energy cut off of the photon and the simulations emanating from the in water. The dose of water distribution was ascertained by using the track length of the MCNP5. As noted by Bolomey & Fred (2001), the simulation points presumed the volume of the polar angles that would be obtained basing on the distribution of the, g(r), d ( and the. The polar angles had a variation of a range of  with respect to 90 degress. The uncertainty of the dosimetric indicates that the variation between the models of 9011125I and 6711 were not significant. The thinner Ag marker has an influence the proportionate of the radionuclide taking the model of 9011 having a percentage that distributes from 2.6% and 4.3%. as the angle affecting the polar value ranges with a percentage of -0.4 percent up to the point where the WAFAC exists. The experiment from the dose function radial indicates the closeness in the values of the 9011 model and the 6711 results in the gL(r) functions (Meigooni, Gearheart & Sowards, 2000). Additionally, the function of the anisotropy was also in tandem with the top model of the 6711 and the 9011 of the bottom model. Apparently, the ratios of the 6711F(r,), the results of the Monte Carlo ranged between 0.098 to 1.03 having the F of radius that ranges from 0.5cm to 7 cm at an angle . In conclusion, the behaviour of the non monatomic also occurred at the vicinity of the source having a longer axis that presumed a value of 6o in the given 9011 model. A decrease in the angle degrees was observed for a non monotonic for a case of a of a 9011 model from 6 degrees to 4 degrees mainly along the plane which was transverse. The angle is also reported to have declined from 73o to 83o. The variation of the 6711 was as a result of the photon protection that emanated from the Ag marker. The source of the model is identified by the use of 1D and 2D forms of the TG-43. This gives an indication that, the derivation of TG-43 dose rate has to be identical. They are used in the preparation of the function of the radial dose that would be found in the 2d anisotropy having the values of its length and functions in g(r, ). References Astrahan, M. (2005), “Improved treatment planning for COMS eye plaques,” Journal of Radiat. Oncol., Biol., Phys. 61, 1227–l242 Chan, G. & Prestwich, W. (2002) “Dosimetric properties of the new 125I BrachySeed model LS-1 source,” Journal of Med. Phys. 29, pp.190–200. Dolan, J., Li, Z. & Williamson, J. (2006). “Monte Carlo and experimental dosimetry of an 125I brachytherapy seed,” Journal of Med. Phys. 33, pp. 4675–4684 Hedtjärn, H., Carlsson, G. & Williamson, J. (2000). “Monte Carlo-aided dosimetry of the symmetra model I25.S06 I125, interstitial brachytherapy seed,” Journal of Med. Phys. 27, pp.1076–1085. Kawrakow, I. (2006). “On the effective point of measurement in megavoltage photon beams,” Journal of Med. Phys. 33, pp.1829–1839. Knutsen, S., Hafslund, R., Monge, R., Valen, L., Muren, P., Rekstad, B., Krohn, J & Dahl, O. (2001). “Domestric verification of a dedicated 3D treatment planning system for episcleral plaque therapy,” Journal of Radiat Oncol Biol., Phys. 51, 1159–1166 Krintz, W. Hanson, F., Ibbott, G & Followill, D. (2003). “A real analysis of the collaborative ocular melanoma study medium tumor trial eye plaque dosimetry,” Int. J. Radiat. Oncol., Biol., Phys. 56, 889–898. Meigooni, A., Gearheart, M & Sowards, K. (2000) “Experimental determination of dosimetric characteristics of Best 125I brachytherapy source,” Journal Med. Phys. 27, pp. 2168–2173. Nag, S., Wang, H., Wu, C., Bauer, R., Chambers, B. and Davidorf, F. (2003) “Custommade “Nag” eye plaques for 125I brachytherapy,” Journal of radiat Oncol., Biol., Phys. 56, pp.1373–1380. Nath, R. & Chen, Z. (2007) “Silver fluorescent x-ray yield and its influence on the dose rate constant for nine low-energy brachytherapy source models,” Journal of Med. Phys. 34, pp. 3785–3793. Reniers, B., Vynckier, S. & Scalliet, P. (2001). “Dosimetric study of the new InterSource125 iodine seed,” Journal of Med. Phys. 28, pp. 2285–2299. Rivard, M. (2007). “Brachytherapy dosimetry parameters calculated for a 131Csource,” Journal of Med. Phys. 34, pp.754–762. Taylor, R., Yegin, G. & Rogers, D. (2007). “Benchmarking Brachy- Dose: Voxel-based EGSnrc Monte Carlo calculations of TG-43 dosimetry parameters,” Journal of Med. Phys. 34, pp.445–457. Williamson, J. (2000) “Monte Carlo modelling of the transverse-axis dose distribution of the model 200 103Pd interstitial brachytherapy source,” Journal of Med.Phys. 27, pp.643 654. X-5 Monte Carlo Team. (2003). MCNP. A general Monte Carlo N-Particle transport code, Version 5, Los Alamos National Laboratory, Los Alamos, NM, Read More

TG43 protocol, how they are obtained In order to obtain the TG-43 dosimetry, the techniques of the Monte Carlo methods are employed. This occurs at the photons that exist at a low energy that exist in the brachytherapy having the form of (18125I and 9103 Pd) (X-5 Monte Carlo Team, 2003).This is achieved by measurement of the thermoluminescent LiF of the solid water dosimeters. The micro tubes were obtained via descriptive and experimental techniques so as to obtain the parameters that are associated with the TG-43 (Reniers, Vynckier, & Scalliet, 2001).

In order to obtain the depth of the of the water and air curve dose, the experiment used the radio chromic film that were acted in the ionization chamber with the aid of the spectrometer using the x-rays as noted by Krintz, Hanson, Ibbott, & Followill (2003). This aids in the distribution of the radiation that were obtained in the strength of the air kerma as noted by Chan & Prestwich (2002). There is need to have the broadening so as to enhance the accommodation of the effect of the current that emanates from the beam.

In order to obtain the TG -43 dosimetry, the use of the finer resolution which are spatial are utilised. They involve the use of parameters such as the dose radial functions, data from the anisotropy and the dose rate constants. In medical field, the protocol obtained follows the form (TG-43) that establishes the functioning of the brachytherapy that finds their application in the interstitial collaborative Working group (ICWG). The dosimetry parameters of the TG-43 occur as a property of the distance obtained from the seed and the polar angle, which are related to the various axes.

This utilizes the aspect of the anisotropy that leads to the bilinear interpolation to the point where the voxels are located. The dose values which are obtained are divided by their initial parameters so as to improve the accuracy of the results that would be obtained. The resultant leads to the values of L(r, ) that has a relationship with the geometric centre. The results from the comparison of the two dose rates indicate that there was favourable dose function in relation to the geometry function.

The dosimetry of the TG-43 seems to be consistent with the radionuclide that emanates from the brachytherapy that are commonly known. The limitations that emanate from this experiment is the uncertainties of the values that were obtained. The utilization of the TG-43 finds their commercial application in treatment process that has a permanent treatment process that acts on prostate brachytherapy. Presently, the use of the TG-43U1 utilizes a single dataset that uses the distribution of 1D and 2D dose rate.

Apparently, the photon emitted from the low energy was believed to treat cancer and even the therapy of the eye plaque that were associated with the permanent implants of the lungs. The generation of the (2D) dose rate of the TG-43 is identified as the dose rate that is related to the P (ro, o) and the SK. The  takes the form of cGyh-1U-1 that is reduced to cm-2. The value of  is defined as . The nature of the dose constant would depend on the source model and the form of radionuclide that would have an effect in the experimental technique.

When this conditions are adhered to, the dose of the TG-43 would have a reproduction that was anticipated and related to the Monte Carlo dose rates emanating from F(r,  ) and g(r) as noted by Dolan, Li & Williamson (2006). In a situation where there is a 1D anisotropic function, the factor of the TG-43 would be identical to the  having a radial distance that takes the form  that is relate from the ratio of the average weight and the angle of the solid weight over a given steradian space.

Monte Carlo simulation This appears apparent in the small size of the brachytherapy seeds that are associated with the implantation of the interstitial by using the needles that have small diameter as noted by Taylor, Yegin & Rogers (2007). Cases of health issues may emanate from the utilization of needles that have a smaller diameter.

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