Existence of cystic fibrosis has been known for a very long time from stories of old cleaning ceremonies where foreheads of children were licked to see if they were salty and if they were those children were feared to die soon due to the disease which we today call cystic…
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nifestation of the disease in the form of pancreatic malabsorption considered to be due to pancreatic abnormalities with evidence from histological changes at autopsy was reported (Parmalee, 1418-1428; Hess and Sapphire, 1-13). Another important clinical feature included severe respiratory problems in affected children. Other significant report of pancreatic changes with features compatible to that of cystic fibrosis came from Margaret Harper of Sydney who reported congenital steatorrhea due to pancreatic defect (Harper, 45-56). However the recognition for describing cystic fibrosis as a separate clinical entity goes to Dr Dorothy Andersen who described neonatal intestinal obstruction, respiratory complications and characteristic pancreatic histology in her 1938 report (Andersen, 344-399). She called it the ‘fibrocystic disease of the pancreases. In the forties it was recognized as a generalized disorder affecting organs other than the pancreas and Dr Sydney Farber who coined the term ‘mucoviscidosis’ for the condition accurately summarized the secondary consequences of Cystic fibrosis to cause clogging of respiratory tract by thick mucus, secondary Staphylococcal infection and failure of proper lubrication of ciliated epithelium (Farber, 827-833).
The first suggestion of cystic fibrosis being an inherited disorder came from Philip Howard who reviewed familial occurrence of the fibrocystic disease of the pancreas (Howard, 330-332). However the first clear report that identified cystic fibrosis to be inherited as a recessive Mendelian trait came from Andersen and Hodges in 1946. They investigated 56 families from literature and 47 of their own families to come to the conclusion that the incidence of the disorder follows the Mendelian recessive inheritance which approximated the incidence in siblings as 25% as expected of a Mendelian recessive condition which required more than one factor for expression (Andersen and Hodges, 62-80).
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(Cystic Fibrosis Research Paper Example | Topics and Well Written Essays - 1000 Words)
“Cystic Fibrosis Research Paper Example | Topics and Well Written Essays - 1000 Words”, n.d. https://studentshare.org/miscellaneous/1563797-cystic-fibrosis.
days on and 28 days off, (currently on course of gentamycin x 10 days) Nasal spray; Atrovent spray 1 squirt each nostril 2x/day, Nasonex: 1 squirt each nostril 1x/day Ultrase MT 12,000 units of lipase: 3 caps with meals & 2 with snacks Prilosec: 20 mg 2x/day Levemir insulin: 22 units at dinnertime Novolog: 2 units at bedtime Formula: via PEG: Vital HN 3 packs mixed with 500 mls water at rate of 75cc/hr for 10 hours nocturnal feeds Scandishake nutritional supplement mixed with whole milk (240 cc) 1-2 x/day Multivitamin daily Vitamin C: 500 mg 1x/day Vitamin D 2,000 IU/day Align probiotics: OTC ( over the counter) Periactin 4 mg 1x/day (stopped as of mid 2009) Pulmonary Function test: 3/2/2010:
Respiratory therapists plan and diagnose pulmonary care. They mostly work single-handedly but sometimes as part of a group. Physicians consult them for treatment of patients with respiratory diseases. He works along side the other portion of the staff in the hospital that provides direct patient care.
The title contains the population and the variable. The authors of the article are employees of Columbia University, department of physicians and surgeons. The introduction provides sufficient information concerning the study since it identifies the significance of the study. The purpose of the study is clearly identified in the introduction that is to prove that asioloGM1 is a receptor of P.
Cystic Fibrosis has been identified as a progressive disorder that affects thousands of people and often results to fatalities. To better provide insight of cystic fibrosis, an intricate understanding is essential on its historical evolution, causes, signs and symptoms, prevalence rates, treatment and management.
sequence): Isoleucine+ glycine + asparagine + Aspartic acid + proline + STOP What is the significance of the first and last codons of an mRNA transcript? Explanation: The significance of the first codon is that it determines signals the beginning of a translation point, usually AUG, which signals the inclusion of methionine.
The particular gene is called the protein cystic fibrosis transmembrane regulator (or CFTR) and people without cystic fibrosis (CF) have two copies of this specific CFTR gene. Only one CFTR gene is needed for the people to avoid CF and this ailment manifests only when both CFTR genes malfunction.
The effects of CF are devastating, but life expectancy in the last 70 years since it was first written about has increased from almost certain death in infancy to 37 years of age. The following paper discusses the nature of CF through a brief
The disease usually affects the liver, intestines, pancreas, lungs and sex organs (Rosaler 2007).
Mucus provides a lining cavity to the organs, and individual suffering from the disease has mucus that is sticky
There are several medications and airway clearance therapies available to treat Cystic Fibrosis. When the disease process advances to end-stage, one option available is bilateral lung transplantation.
Cystic fibrosis is a common recessive disorder
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