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Multiple Sclerosis Disease - Research Paper Example

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This paper is out to examine the impact of Multiple Sclerosis on gait pattern. The research has a lot of significance associated with it following the fact that locomotion has proved to be not only basic but an essential part of the human transportation…
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Multiple Sclerosis Disease
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Download file to see previous pages This condition commonly progresses to stages of significant disability and reduced quality of life for the patient. Prevalence of Multiple sclerosis (MS) in UN is around 58 to 95 per 100 000 and it is estimated that in the US there about 400 000 patients with MS (Noseworthy et al., 2000, p. 950). There is a substantial research that is explaining the pathogenic mechanisms of the disease; however, the etiology of MS is still an object of debate. Many theories have been proposed as the causative agent for this condition. By some extent MS is considered to be an inherited condition because the incidence of MS is found to be higher in families with a case of MS and this is especially true for the siblings and children on patients with MS. Also, genetic testing has already identified some genes of the major histocompatibility complex that are associated with MS, especially DR-15 and DQ-6 genes (Compston and Coles, 2008, p.1550). Other theories calculate with environmental factors like lack of sun exposure, vitamin D deficiency, stress, smoking and other factors (Ascherio and Munger, 2007, p. 290). Infective theory tries to connect MS with increased hygiene in the modern world and lack of nonspecific stimuli of the immune system or it connects it with some viral infective agents like human herpes virus, Epstein-Bar virus (Ascherio and Munger 2007). In order to investigate the effects of Multiple Sclerosis on gait pattern, MRI was used in the study of the nervous system and the spinal cord of MS patients. Being an idiopathic inflammatory disorder, MS mostly affects the central nervous system characterized by subsequent axon and degeneration. Now that the disease mostly affects the aged with symptoms such as weakness, numbness, loss of balance, visual impairment, fatigue, urinary bladder urgency, and dizziness, it can be easily confused with other old aged disorders (Arnold and Mathews, 2002, p. 24). ...Download file to see next pages Read More
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