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Prostate Cancer in the United States of America - Research Paper Example

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The document describes how to provide a comprehensive description of the burden of prostate cancer in the United States of America. The cancer of the prostate gland is one of the major leading causes of death of men, especially of advanced age…
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Prostate Cancer in the United States of America
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Download file to see previous pages Prostate glands, an integral part of the male reproductive system is a walnut-sized gland located in between the penis and the rectum, under the urinary bladder. Cancer of the prostate glands involves a multifocal primary tumor of varying intensities. The primary tumors originate from the epithelial cells of the prostate and produce a range of prostate cancer associated antigens such as prostatic acid phosphatase, human kallikrein 2, prostate stem cell antigen and prostate specific membrane antigen along beside the prostate-specific antigen (PSA) or human kallikrein 3. These tumors respond to androgen and their growth is at least partially regulated by it; though in advanced stages they cease to remain androgen-dependent and enter the scattered disease state. Lymph nodes and skeleton at this stage exhibit metastases with bones being exceptionally vulnerable to prostate cancer. Moreover, unlike most other tumors, metastases in bone disturb the normal bone remodeling causing an osteoblastic response distinctive of prostate cancer. Immense pain and morbidity in the prostate are attributed to this osteoblastic response (Corey & vessel, 2007). Prostate cancer has been reported to be the second leading cause of death of men in the west and the second most common form of cancer in men (Quinn & Babb, 2002). The incidences, mortality, and prevalence of the disease exhibit striking correlation with race, diet and lifestyle patterns. Further significant geographical variations are also observed in the occurrence of the disease. ...Download file to see next pages Read More
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