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Hypothermia Post-Cardiac Arrest - Research Paper Example

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Inclusion criteria for the paper included an initial cardiac rhythm of ventricular fibrillation at the time of arrival of an ambulance, successful return of spontaneous circulation, persistent coma after the return of spontaneous circulation, and transfer to emergency departments…
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Hypothermia Post-Cardiac Arrest
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Download file to see previous pages This paper tells that exclusion criterion included the following: age of fewer than 18 years for men and 50 years for women, cardiogenic shock (systolic BP of less than 90mmHg despite epinephrine infusion), or possible causes of coma other than cardiac arrest. Patients who were in the hypothermia group underwent initial cooling measures in the ambulance and when they arrived in the hospital, they underwent vigorous cooling in the ED through the application of ice packs around the head, neck, torso, and limbs. As soon as their core temperature reached 33 degrees Celsius, the ice packs were removed and their temperature was maintained until 12 hours from their arrival at the hospital. They were kept sedated and paralyzed with small doses of midazolam and vecuronium to prevent shivering. At 18 hours, the patients were rewarmed for the next 6 hours through external warming methods; they were kept sedated. Those assigned to the normothermia group were also sedated and paralyzed with their target core temperature at 37 degrees Celsius. Passive rewarming was applied to patients if there was mild spontaneous hypothermia on arrival. After 24 hours, patient care based on ICU protocols was applied. Patients who regained consciousness went through extubation and were transferred to the coronary care unit. Active life support was withdrawn for patients who remained deeply comatose for 72 hours. Results revealed that the demographic characteristics of the patients were similar in both groups. Twenty-one out of the 43 patients treated with hypothermia survived and presented with a good outcome; 9 out of 34 treated with normothermia presented with a good outcome. The odds ratio for good outcome with hypothermia in relation to normothermia was at 5.25. ...Download file to see next pagesRead More
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