Nobody downloaded yet

Epidermolysis Bullosa - Research Paper Example

Comments (0) Cite this document
Epidermolysis bullosa Name University Epidermolysis bullosa Part One Epidermolysis bullosa (EB) is an inherited disorder of the epithelial layer or surface tissue of the skin which leads to recurrent blisters and erosions in the affected individual. Even a minor case of injury or strain will lead to damage of the cell structure and tissues…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER98.5% of users find it useful
Epidermolysis Bullosa Research Paper
Read TextPreview

Extract of sample "Epidermolysis Bullosa"

Download file to see previous pages The earliest evidence of bullous skin disorders of genetic type are found to be mentioned by Hebra, Fox and Goldsheider (Lin & Carter 1992). Koebner was the first person who coined the term epidermolysis bullosa hereditaria in 1886. He used the term to describe and elaborate a set of family generations that have been showing the skin blistering and erosions for many years. The term hereditaria described its hereditary origin, bullosa for the blistering manifestation and epidermolysis for the lysis of the epidermis layer of skin. Hallopeau was the second person who analyzed two different forms of the disease; epidermolysis bullosa simplex (EBS) and dystrophic epidermolysis bullosa (DEB). He described that the simplex form was caused by the blistering lesions only in the epithelial layer of the skin and they do not leave a scar mark. The dystrophic variant occurred in the sub-epithelial layer of the skin and was scarring in nature (Keefe 2008). Until 1935, they were thought to be the only two types of EB. However, in 1935 Herlitz put forward another variant which was more severe in its manifestations and had poor prognosis. This variant was termed as EB letalis. Junctional EB (JEB) was another name given to this type and is more commonly used. The rationale for using this term was that it affected the junction between the cell membrane and the basement membrane. In the 20th century proper classification was put forward on the basis of clinical manifestations of every type. In 1991, the molecular genetics of the EBS were found to be caused by the mutations in the keratin 5 and keratin 14 genes. Electron microscopy advancements made it possible to describe the JEB, DBS and EBS at an ultra structural level and understand the histopathology of the disease (Keefe 2008). Currently four major types of EB have been established; EB simplex, junctional EB, dystrophic EB and Kindler syndrome. EB simplex is described by its intra-epidermal erosions and blisters. Two further sub-types of EBS include localizes EBS and generalized EBS. An important type of generalized EBS is EBS-Dowling Meara which leads to death in the infant years of life. Other types include EBS with mottles pigmentation, EBS with muscular dystrophy, EBS-Ogna and autosomal recessive EBS. The junctional EB and dystrophic EB are characterized by erosions and lesions in the lamina lucida and sub-lamina densa, respectively. A severe form of JEB is termed as JEB-Herlitz and involves all the skin surfaces of body. Inverse JEB, non-Herlitz JEB, LOC syndrome and JEB with pyloric atresia are some other clinical sub-types of JEB. Two major sub-types of DEB arete dominant and recessive dystrophic EB. JEB of all the sub-types has the poorest prognosis and leads to death during the early years of life. DEB and EBS patients have a comparatively good prognosis and have a normal life expectancy (Fine 2010). EB dystrophica is one of the most severe forms of the EB four types. The alternate names used for this condition are dermolytic EB and dystrophic EB. The individuals suffering from this type have very delicate skin and it can tear off as a result of even mild trauma or friction. They present with blisters and erosions which associated with intense pain and generalized pruritis. The erosions are mostly scarring and heal with an atrophic scar. Nails are also affected and ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
(“Epidermolysis Bullosa Research Paper Example | Topics and Well Written Essays - 1000 words”, n.d.)
Epidermolysis Bullosa Research Paper Example | Topics and Well Written Essays - 1000 words. Retrieved from
(Epidermolysis Bullosa Research Paper Example | Topics and Well Written Essays - 1000 Words)
Epidermolysis Bullosa Research Paper Example | Topics and Well Written Essays - 1000 Words.
“Epidermolysis Bullosa Research Paper Example | Topics and Well Written Essays - 1000 Words”, n.d.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document

CHECK THESE SAMPLES OF Epidermolysis Bullosa Research Paper

Toni Morrison the Book Sula and the Symbol of Water

...of their lives. Moreover, water is a symbol of death coming to people in Medallion with the National Suicide Day and to Sula and Nel with the death of Chicken Little. All these characterizations are taken by Morrison to symbolically evoke to a reader’s sensitivity so as to realize the scope of oppression and hardships African American got through and still coping with within the American social life. Works Cited Bloom, Harold. Toni Morrison's Sula. New York, NY: Infobase Publishing, 1999. Davis, Anita Price. Toni Morrison's Sula. Washington DC: Research & Education Assoc., 1998. Duvall, John Noel. The identifying fictions of Toni Morrison: modernist authenticity and postmodern blackness. New York, NY: Palgrave Macmillan, 2000....
5 Pages(1250 words)Essay


... Recent development in healthcare demands greater efficiency in the dispensation of health care . The expansion of coveragetowards the less privileged sectors in society with the expansion of Medicaid and Medicare and shift in emphasis from treatment towards preventive care calls for a greater for health care practitioners that includes nurses because persons who were not previously covered by health care will now be included. People who were previously classified as “sicker” that were shunned away by insurance companies are now covered thus expanding the responsibilities of health care practitioners particularly the nurses. The new order in health care now calls for greater efficiency, more empowerment and better care albeit aimed... Recent...
4 Pages(1000 words)Essay

Analysis of The Secret

...? Analysis of ‘The Secret’ The Secret film is based upon the ‘law of attraction’ and positivity. It explains how one can actually benefit through aligning one’s thinking with the real desires and wants. The concept of positive attraction as described in the film revolves around the emission of positivity from within one’s own self, which in return attracts positivity from the external world and ultimately makes an individual become more successful in his life (Byrne). The film explicit that human mind is full of negative and positive thoughts. However, in the overall thinking process either positivity or negativity gets complete hold of the mind. If the mind is under the control of positive attraction then things that people plan to achieve...
3 Pages(750 words)Essay

Stem Cell

...application in treating Epydermylosis Bullosa is a good example. Successful gene therapies and treatments in the management of the condition were realized in 2010 and 2013. The stem cells were also used earlier and by 2009, bone marrow transplants were used to remedy conditions. Research is also being furthered to establish whether the stem cells can be used in the treatment of leukemia, brain injuries, and cancer among others. Stem cells provide a positive prognosis if well applied and intensive research done before the use. For instance, advice is given that one should select a sustainable and appropriate stem cell for any therapy and treatment. Though there are fears that stem cells cause cancer if the build up and...
4 Pages(1000 words)Research Paper

Wollstonecraft and the Rights of Women: Chapter II The Prevailing Opinion of a Sexual Character Discussed

Wollstonecraft calls herself a philosopher (58.1), but philosophy is basically considered rational thinking, reflective and logical, not an outlook on life. She, however, offers a passionate, mostly one-sided argument for the education of women by setting forth her interpretation of the beliefs of notable male writers who have defined women in different ways with the same result, i.e. Milton, she says, believes women are innocence personified, formed for softness and sweet attractive grace. Wollstonecraft disagrees, saying, "Children should be innocent, but when the epithet is applied to men or women, it is but a civil term for weakness" (4.12-13). Through this entire chapter, Wollstonecraft intentionally uses language designed to show men...
2 Pages(500 words)Essay

Personality theories

...Personality theories Find two articles about George Kelly and/or his theories. Post the url for each of them as separate threads, and include a few sentences about each article and its source. George, A. K. (2012). Ecology of Mind. Retrieved Feb 12, 2013 from Apart from his bibliography, the article discuses George’s Personal Construct Psychology theory, which focuses on the effort a person, makes in order to build self. According to him, one has to face challenges and confusion while discovering life. In order to become successful, an individual needs to overcome the threats or challenges in order to become or identify self. George, A .K. (2012). Confusion and the Clock. Retrieved Feb 12, 2013 from http... theories...
5 Pages(1250 words)Assignment

Grunge Fashion

...Fashion 1980- Now: Grunge Fashion Grudge fashion is a style believed to have its roots in Seattle, United s and was most popular during the late 1980s and throughout the 1990s. The style was influenced by the economic slump that defined the U.S economy as well as the fast growing pop music genre where popular rock bands such as Nirvana were defined by grudge fashion. In the above picture, the most typical elements of Grudge are depicted. The common checkered flannel shirt that was generally oversize with toned-down colour imprints. The shirt is worn un-tucked owing to its woolen nature. The shirt is mostly unbuttoned but layered with a t-shirt. Long sleeved shirts could be folded to potentially realize the grudge look. In essence, grudge... 1980- Now:...
1 Pages(250 words)Essay

Construction Legal Procedures

...of service delivery, are taken care of in single contracts for every particular trade (Moran and Stover, 1993, pp.1-14) . In Express terms, incorporation in the absence of reference is dependent upon the objective of the entities involved. Once the express terms have been recognized, they must be interpreted. The papers spelling out the entities’ agreements must be interpreted without prejudice. It is not the actual intention of one party or what the other entity understood to have been intended that matters, but what an unbiased and objective individual in the position of the entities would have interpreted the actual statements to mean (Moran and Stover, 1993, pp.1-14). The first stage in assessing the unbiased meaning is the...
6 Pages(1500 words)Essay

Technical proposal assignment

...Record Management System Problem and its Significance Using computers in teaching English for young learners is important and is vital in enhancing the performance of the students and the overall performance of an organization. The college I work for currently do not have an integrated students record management system that captures all the students data from admission, fees payment, programs taken, learning timetable, assessments, examinations, results and grading. The current status of management of students’ records in my department involves a lot of paper work and filing that predisposes the department to risk of loss of finances and data. In this regard, my institution is not able to accurately and timely analyze students’...
4 Pages(1000 words)Assignment


... LinkedIn Question One Net Revenue Growth Trends The growth of Linked income has decreased annually. The year marked the highest growth in income to 115% that had increased from 102% in 2010. From that point onwards, the level of income fell from 86% in 2012 to 45% in 2014. The primary determinant of net revenue is the net sales. In 2010, there was a significant potential growth of the market. The customers were more willing to buy the products of the company. From 2011, the competition increased continuously. The growth may also reduce in future because the company may have already exploited the large customer base available (Sherman 56). The net growth of net income is different from net revenue. The interaction between costs and the net...
1 Pages(250 words)Essay
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.

Let us find you another Research Paper on topic Epidermolysis Bullosa Research Paper for FREE!

Contact Us