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Pathophysiology of Alzheimers Disease - Research Paper Example

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This research "Pathophysiology of Alzheimers Disease" aims to represent a brief overview of Alzheimer's disease, its first known case and symptoms and requirements for treating…
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Pathophysiology of Alzheimers Disease
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Download file to see previous pages Alzheimer’s disease (AD), which accounts to about two – thirds of diagnosed cases of dementia, is characterized by a progressive neurodegenerative dementia in the elderly and progressive cognitive decline that results in gradual and irreversible memory and cognitive loss (Yaari and Bloom, 2007, Wayne, et al, 2009, and Yamasaki, et al, 2012). AD is an incurable disease that is believed to be an acquired impairment in cognition and behaviour that hinders markedly with the social and occupational performance of an individual (Anderson, 2011). AD is difficult to diagnose because patients may initially have a normal IQ functioning. At the onset, patients may have memory, language, and visuospatial deficits, which would later progress to depression, obsessive, suspiciousness, anger outburst, and violent acts (Anderson, 2011). The aforementioned characteristics of AD bring detrimental effects on the patients as well as duties and responsibilities on the family and caretakers of the patients (Anderson, 2011).
The first reported case of Alzheimer was made in 1901 by Dr. Alois Alzheimer, a German psychiatrist, who observed a patient who suffered from short term memory loss at the Frankfurt Asylum. The patient eventually died in 1906 and, and Dr. Alzheimer sent her brain together with the medical records to Munich. Together with Dr. Kraeplin, Dr. Alzheimer noted amyloid plaques and neurofibrillary tangles on his histological findings by staining section of the brain of the patient (Yaari and Bloom, 2007 and Anderson, 2011)....
History of Alzheimer’s Disease The first reported case of Alzheimer was made in 1901 by Dr. Alois Alzheimer, a German psychiatrist, who observed a patient who suffered from short term memory loss at the Frankfurt Asylum. The patient eventually died in 1906 and, and Dr. Alzheimer sent her brain together with the medical records to Munich. Together with Dr. Kraeplin, Dr. Alzheimer noted amyloid plaques and neurofibrillary tangles on his histological findings by staining section of the brain of the patient (Yaari and Bloom, 2007 and Anderson, 2011). The pathology and clinical symptoms of Alzheimer’s disease (previously known as presenile dementia) was presented by Dr. Alzheimer in his speech in 1906, and subsequently published his findings in the year 1907.   Pathophysiology of Alzheimer’s Disease Anderson (2011) stated that alzheimer’s disease normally affects the three processes that maintain a healthy neuron. These are communication, metabolism, and repair. Any disruption of these processes may cause certain nerve cells in the brain to be ineffective, losing its connections with others neurons, and ultimately lead to cell death. As a result, memory starts to fail causing changes in the personality of a person, and difficulty in achieving day to day activities (Anderson, 2011). Alzheimer’s disease (AD) has a complex pathophysiology since it involves pathophysiologic processes and neurotransmitter systems (Morrison and Lyketsos, 2005, and Siegal, 2005). The three (3) well – known and central factor in the neurodegenerative process as well as the universally accepted hallmark of AD described by Dr. Alzheimer in his 2007 ...Download file to see next pages Read More
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