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Effect of Exercise on Skeletal Muscle - Coursework Example

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"Effect of Exercise on Skeletal Muscle" paper determines whether there are any alterations in the metabolic and mitogenic pathways in skeletal muscle physiology of normal persons and highly trained athletes. The stimulus for this study was provided by past research…
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Effect of Exercise on Skeletal Muscle
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Download file to see previous pages Alterations in glycogen metabolism, glucose and amino acid uptake, protein synthesis, and gene transcription have been well documented (Widegren et al, 1998), but the mechanisms involved are still unclear. Intracellular signaling mechanisms after a skeletal muscle is subjected to intense exercise result in changes to gene expression which has resulted in many putative elements to be studied, prominent amongst them being the Mitogen-activated protein kinase (MAPK) which has two parallel pathways including the extracellular signal-regulated kinase (ERK), stress-activated protein kinase cascades (SAPK1/JNK) and the extracellular signal-regulated kinase 5 (ERK 5) and 5`-AMP-activated protein kinase (AMPK) cascades (Mei Yu et al, 2002). The physiological activation of enzymes downstream of the MAPK cascade has been under intense study (Krook Anna et al). It is a major signaling system by which cells transducer extracellular signals into intracellular responses (Aronson Doron et al, 1997). The overall impact is a marked alteration in the structure and functioning of the human skeletal muscle. Exercise not only affects the upstream cascade of the MAPK cascade but also increases the activity of upstream regulators of MAPK and other associated molecules (Aronson Doron et al, 1997).

Numerous studies have been conducted on this aspect and this study (Mei Yu, et al, 2002) in particular focuses on MAPK and AMPK cascades by comparing them in volunteers chosen from two groups, one group involving highly trained cycling athletes and the other one of normal/control persons, by subjecting them to pre-calculated equivalent exercise stress according to their capacities, to further differentiate if there are any changes in the cascades between the two groups. The oxygen uptake of the two groups has also been strategically predefined in order to provide similar inputs to both groups in order to avoid abnormality in the result due to this factor. ...Download file to see next pagesRead More
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