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Pharmaceutical Evaluation Report: The drug is Singulair - Literature review Example

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The drug singulair is a drug that is an inhibitor of leukotriene. Leukotrienes are chemicals that the human body releases. These chemicals are released when people breathe in and out pollens which are considered to be allergens…
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Pharmaceutical Evaluation Report: The drug is Singulair
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Download file to see previous pages The drug is also used to relieve sneezing that is as a result of allergies and runny noses, on both and children. The drug should never be administered without the doctor’s advice. The drug is also used prevent bronchoconstriction in children during exercising. Bronchoconstriction results during exercising and the air passage ways narrow in the lungs. A. Invention of the drug Its chemical IUPAC Name is 2-[1-[[1-[3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methyl-ethyl] The molecular formula for the drug is C35H36ClNO3S The diagram below shows its chemical structure The drug was discovered by scientists who wanted to understand the genetic makeup of human beings. Receptors were the background study of this drug and the main receptor for this drug was the cysLT1 receptor. This receptor was discovered in 1999 and the receptor was referred to as a gene. The discovery was as a result of human characterization of the cysteinyl leukotriene receptor. This was also referred to as CysL T 1 receptor. It is well understood that leukotriene 4, leukotriene D4, and leukotriene C4 are some of the important mediators in of bronchial asthma in humans. Pharmacological studies have shown that the cysteinyl Leukotrienes usually activate a minimum of two receptors (Monson, 2008). The receptors are designated CysLT2 and CysLT1. Singulair is a selective antagonist against CysLT-1. Other selective antagonists include Accolate and Onon. These drugs are believed to be quite important CysLT 1 antagonists and its receptors. Pharmacological and molecular characterization was reported for the cloned CysL T1 receptor. It was detected that CysL T1-receptor messenger RNA peripheral leukocytes, lung and spleen. It is believed that the expression of the CysL T1-receptor mRNA was only confined to tissue macrophages and the smooth muscle cells. It was finally mapped out that the CysL T1-receptor gene was linked to the X chromosome. Biological mode of action of the drug Singulair The formulation of the drug singulair is in the tablet form. The formulation is usually a 10mg with an active ingredient that is known as montelukast (Nevoigt, 2009). Montelukast is type of medication that is known by many pharmacologists as a leukotriene receptor antagonist. The drug works by blocking or simply inhibiting leukotrienes from performing their functions. Leukotrienes are chemicals that are usually released during inflammatory and allergic reactions by the human body (Dubrin, 2011). People with asthma usually release leukotrienes which result in inflammation and high levels of mucous production within the airways. The other effects that are caused by leukotrienes include contraction of the muscle lining that result in the contraction of the airways. This contraction makes it quite difficult for the air to get into the lungs and out. The drug montelukast works by inhibiting the receptors that are found in the lungs. By inhibiting the receptors, action by leukotrienes are inhibited and this prevents the production of excess mucous in the lungs. Narrowing and inflammation of the airways is also prevented hence an individual cannot suffer from an asthma attack. The drug montelukast is normally used by people or recommended for people who never get treated by using inhaled corticosteroids. The drug is usually used in addition to other medicines such as salbutamol. Leukotrienes are also produced by people who suffer from ...Download file to see next pagesRead More
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