How drug abuse is linked to depression
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In one of the study by Regier et al. (1990), a link has been established between coexistence of drug dependence and depression; a cycle which leads to self-medication with involvement of same neurotransmitter family in both the cases. Similarly, further elaborating this point is the fact that in an article by Markou and Kenny (2002), it has been argued that there are similar pathophysiological mechanisms in drug dependence, depression and negative effects of schizophrenia. It has been shown that there are adaptive changes in the brain in response to prolonged exposure to the drugs of abuse which act as a mechanism to oppose the immediate effects of the administered chemical (Markou et al., 1998; Koob et al., 1993).