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RU486 - Essay Example

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It is an antiprogestogen drug used for the non-surgical termination of pregnancy up to 24 weeks of gestation (Medic8 “Health Guide”). It is otherwise known as the abortion pill. In order to carry…
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Download file to see previous pages... The mechanism of action of RU486 is that it sensitizes the myometrium to prostaglandin-induced contractions and then softens and later dilates the cervix; the Gemeprost would then stimulate the uterus to contract and expel the fetus (Medic8 “Health Guide”).
The drug is to be taken with precaution among asthmatics and among those with blood disorders or those taking anticoagulant medications (Medic8 “Health Guide”). This drug cannot be taken by smokers aged 35 years and above. Moreover, Aspirin and NSAIDS should be avoided while taking RU486 as it can increase bleeding (Medic8 “Health Guide”). It is contraindicated in uncontrolled severe asthma, suspected ectopic pregnancy, chronic adrenal failure, and porphyria (Medic8 “Health Guide”). Its side effects include nausea and vomiting, abdominal cramps, and possibly severe vaginal bleeding (Medic8 “Health Guide”). In case the abortion is not successful, it is advised that other means of abortion be applied in order to complete the abortive process (Medic8 “Health Guide”).
Some of the issues with this drug are related to the fact that no actual testing has been performed on the drug before it has been released into the market. Apparently, the only testing which has been conducted on the product before 1988 was a test to determine dosage. Such tests did not resolve or address the drug safety in actual usage (MacDonald “RU486). Large scale testing of the drug has been conducted in France and in England and the reports reveal alarming results for women. Severe and violent side-effects on women have been seen after administration of this drug. These side-effects included nausea, headache, diarrhea, vomiting, and bleeding and the bleeding has been known to last up to 35 or 40 days with an average duration of 8 to 10 days; some women actually required blood transfusions after profuse bleeding following administration of this drug (MacDonald “RU 486”).
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