We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Nobody downloaded yet

Phosphoaspirin (MDC-43) a novel benzyl ester of aspirin, inhibits the growth of human cancer cells - Essay Example

Comments (0) Cite this document
Nonsteroidal anti-inflammatory drugs (NSAIDs), specifically aspirin, have been shown to prevent colon cancer and a few other forms of cancers, however, their effect is weak and there are many side effects associated with their persistent use. Therefore, improved forms of aspirin…
Download full paper
Phosphoaspirin (MDC-43) a novel benzyl ester of aspirin, inhibits the growth of human cancer cells
Read TextPreview

Extract of sample
Phosphoaspirin (MDC-43) a novel benzyl ester of aspirin, inhibits the growth of human cancer cells

Download file to see previous pages... This study by Zhao, Mackenzie, Murray, Zhang, and Rigas (2009) aims to observe the anticancer activity and mechanism of the new phosphoaspirin (MDC-43). For the purpose of this study, several reagents were purchased, or gifted, from different pharmacological companies. Cell cultures were grown in the laboratory in line with the American Type Culture Collection instructions. The trypan blue exclusion method was used to measure the cell viability and growth. Moreover, the cell cycles were analyzed following standard PI protocols (Zhao, Mackenzie, Murray, Zhang, and Rigas 2009, p. 512).
Human cancer cells derived from colon, pancreas, breast, liver and lung were used in this study; these are some of the major and most common forms of cancer and account for around “54% of all new cases of cancer in the USA” (Zhao, Mackenzie, Murray, Zhang, and Rigas 2009, p. 517). All cell lines that were studied showed that Phosphoaspirin was more powerful than aspirin in preventing cancer cell growth (Zhao, Mackenzie, Murray, Zhang, and Rigas 2009, p. 513). Moreover, phosphoaspirin was also shown to stimulate the creation of reactive oxygen species (Zhao, Mackenzie, Murray, Zhang, and Rigas 2009, p. 514). The study also observed that phosphoaspirin had an inverse effect on thiol levels in the cells, and produced intrinsic apoptosis (Zhao, Mackenzie, Murray, Zhang, and Rigas 2009, p. 514-516). Furthermore, the phosphoaspirin also increased cell signaling in some cells, however, the effect was limited to protein activation alone (Zhao, Mackenzie, Murray, Zhang, and Rigas 2009, p. 516).
The data collected by the study clearly demonstrated that phosphoaspirin has a strong reduction effect on human cancer cells. Moreover, the effect is stronger than that of aspirin, as well as being more generalized. The strength of phosphoaspirin was found to be more uniformly superior to ordinary aspirin; however, no reason ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
(“Phosphoaspirin (MDC-43) a novel benzyl ester of aspirin, inhibits the Essay”, n.d.)
Retrieved from https://studentshare.org/miscellaneous/1564812-phosphoaspirin-mdc-43-a-novel-benzyl-ester-of-aspirin-inhibits-the-growth-of-human-cancer-cells
(Phosphoaspirin (MDC-43) a Novel Benzyl Ester of Aspirin, Inhibits the Essay)
“Phosphoaspirin (MDC-43) a Novel Benzyl Ester of Aspirin, Inhibits the Essay”, n.d. https://studentshare.org/miscellaneous/1564812-phosphoaspirin-mdc-43-a-novel-benzyl-ester-of-aspirin-inhibits-the-growth-of-human-cancer-cells.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document
Human Growth and Development
This paper addresses the major growth processes in two-year old infants. It provides a summary of Berger’s The Developing Person through the Lifespan chapters five, six, and seven. The summary to chapter five highlights the physical growth of infants. This includes the acquisition of different motor skills and other biosocial development processes.
6 Pages(1500 words)Essay
Human Growth and development
Some researchers support the argument that nature is responsible for the makeup of an individual’s behavioral patterns which can be modified through interaction with society. They suggest that human beings are not happy or sad because of their environment but individuals are different from each other because of their genetic makeup granted to them by their parents.
1 Pages(250 words)Essay
Human Growth Development
Upon reflecting on the leaders of this country, Kohlberg’s theory differs depending on the age and experiences of the leader. As in the case of former United States President William Jefferson “Bill” Clinton, this theory varies on the different aspects of his life.
1 Pages(250 words)Essay
Human Growth and Development
If I discovered that my teenage child is taking drugs, the first thing that I will do is to be calm and have a heart to heart talk with my daughter. I will first tell her that I love her very much and I am concerned and worried that she is using drugs. I will tell her how I discovered it, specifying that I found some drug paraphernalia in her room and that I have observed some physical changes in her appearance and behavior.
1 Pages(250 words)Essay
Reprogramming of Cancer Cells
Mutations in genes resulting in Cancer: Basically cancer arises due to mutations in different genes which result in the uncontrolled division of the cells which allow these abnormal cells to invade the normal cells of the body. Genes are basically a coding system inside the cell which directs the cell to perform its functions through the synthesis of different proteins which are encoded by different genes.
4 Pages(1000 words)Essay
Stem Cells May Be Key to Cancer
A fear of the misuse of scientific knowledge has marked many of the debates. In contrast to tradition medicine, the main advantage of stem-cell research is that medical professionals will be able to target the causes of a tumors rather than simply treating their symptoms.
3 Pages(750 words)Essay
Aspirin Use and Pancreatic Cancer Mortality in a large United States Cohort
Some point at there being an inverse relationship present, others conclude that there is a direct relationship, while still others show little to no relationship between the two. This study aims to find out whether there is a link between the use of aspirin and pancreatic
3 Pages(750 words)Essay
Cancer Cells
However, even if an organism has reached its development peak, the dwindling of physiological functions continue, until it reaches the endpoint, senescence. For
10 Pages(2500 words)Research Paper
Why it is important study quiescent cancer stem cells
Pece (2010) noticed a link between quiescence and CSCs in breast tumors. The findings from Roesch et al (2010) in melanoma also give indication about linkages
1 Pages(250 words)Essay
Human Growth and Development
Biosocial development entails the study of the body structure, its parts, and subsequent functions. On the other hand, cognitive development enables an individual to understand and appreciate the
4 Pages(1000 words)Essay
Let us find you another Essay on topic Phosphoaspirin (MDC-43) a novel benzyl ester of aspirin, inhibits the growth of human cancer cells for FREE!
Contact us:
Contact Us Now
FREE Mobile Apps:
  • About StudentShare
  • Testimonials
  • FAQ
  • Blog
  • Free Essays
  • New Essays
  • Essays
  • The Newest Essay Topics
  • Index samples by all dates
Join us:
Contact Us