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Hashimotos Disease and an Autoimmune Disorder - Research Paper Example

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The paper describes Grave’s disease as an autoimmune disorder in which certain antibodies are developed in the body against the thyroid gland which includes thyroid stimulating immunoglobulin (TSI), thyroid growth stimulating immunoglobulin (TGI) and TSH binding inhibitor immunoglobulin (TBII)…
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Hashimotos Disease and an Autoimmune Disorder
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Download file to see previous pages Hashimoto's disease is also an autoimmune disorder which leads to the destruction of the thyroid epithelial cells. CD8+ cytotoxic T cells and CD4+ T cells act against the gland leading to the destruction of cells. Other antibodies against the thyroid include anti-TSH receptor antibodies, antithyroglobulin, and antithyroid peroxidase. These lead to inflammation of the gland followed by wear out of cells. Hypothyroidism is the result which leads to enlargement of the gland. The basal metabolic rate drops and bradycardia, weight gain and somnolence are observed. Levels of the thyroid hormones, TSH, antibodies and basal metabolic rate (BMR) are checked in both the conditions. In graves disease thyroid hormone levels are high, TSH levels are low, BMR is high and antibodies specific for this disease are seen. In Hashimoto's disease, the levels of thyroid hormones are low, TSH levels are high, BMR is low and the antibodies specific for this disease are found in the blood. There are four types of diabetes mellitus. Type 1 is known as insulin dependent diabetes mellitus, type 2 is referred to as non-insulin dependent diabetes mellitus, the third type is gestational diabetes and the last one is which occurs due to some genetic or congenital problem. Type 1 diabetes is of early onset which occurs due to the destruction of the beta cells of the pancreas which are responsible for the secretion of insulin. This can be because of autoimmunity against the gland. Type 2 diabetes is of late-onset and occurs due to either the inappropriate secretion of insulin from the beta cells or there is resistance against insulin in the cells that is they do not respond to it. ...Download file to see next pagesRead More
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