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... Hypersensitivity Reactions Hypersensitivity Reactions Hypersensitivity reactions refer to reactions by the normal immune systemsthat are undesirable. They include autoimmunity and allergies. The reactions could be occasionally fatal, uncomfortable, or damaging. In order for hypersensitivity reactions to occur, they need the host to be in a state of pre-sensitization. Gell and Coombs classified these reactions into four groups. These are: allergy, antibody dependent hypersensitivity, immune complex disease, delayed hypersensitivity disease, and autoimmune disease. This paper aims to review the immunological mechanisms giving rise to the four groups of hypersensitivity. It also compares and contrasts...