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Histone Deacetylase Sirtuin 1 - Essay Example

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The summary "Histone Deacetylase Sirtuin 1" describes the main aim of this study was to provide evidence on the negative regulatory function of Sirt1 on the expression of IL-27 and IFN-β. Therefore, Sirt1 constantly interacts with IRF1 at the molecular level and brings about inhibition of IRF1…
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Histone Deacetylase Sirtuin 1
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Download file to see previous pages A comparison was then made of the methylated genes at different stages for their commonality and uniqueness in order to find the pattern across the stages of LUAD. Validation and ranking of the patterns for their significance were made using literature evidence. Consequently, the ranked patterns were later analyzed as potential targets of LUAD. Limitations of the study were also identified including lack of laboratory validation of identified targets and availability of information on TCGA. A number of results were obtained through table analysis. After the assessment, it was observed that the highest number of significant DNA methylated genes were found in stage III and the least in stage I. Upon reviewing the table which listed the common significant DNA methylated genes across and between stages it was found that sampled 10 genes it was found that the three most hypermethylated genes were found to be in stage III. The rest of the genes that were hypomethylated were distributed across stage II and I, with the least hypomethylated in stage I. The above hypermethylated and hypomethylated genes were further analyzed with respect to their methylation inside and outside of the CpG islands. “It was identified that hypermethylated genes in Stages I and III and hypomethylated genes in Stage II were mostly identified in TRUE CpG sites” ( Yang et. al. 37256). When network construction and analysis was done it was found that a greater degree of interaction existed within the significant DNA methylated genes. ...Download file to see next pagesRead More
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