Nobody downloaded yet

Malignancy (Cellular Pathology) - Case Study Example

Comments (0) Cite this document
Summary
Usually, staining (as performed in the image) helps to distinguish normal from cancerous tissue. From the image one can see that compared to the adipose tissue that appears…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER98.6% of users find it useful
Malignancy (Cellular Pathology)
Read TextPreview

Extract of sample "Malignancy (Cellular Pathology)"

Download file to see previous pages In addition, unlike the cancerous squamous cells which appear abnormal and distorted, normal squamous cells look smooth and regular. Deeper analysis focusing on the nucleus would have provided information that identifies and distinguishes normal from cancerous adipose tissue.
The malignant adipose tissue have large nucleus with irregular shape and size. In addition, the nucleoli are prominent; the cytoplasm is scarce and deeply colored or, on the opposite, is pale. The nucleus of malignant adipose tissue plays, through its alterations, a big role in the evaluation of malignancy. Changes are associated with the surface, structure and homogeneity, the nucleus/cytoplasm ratio, volume, as well as shape and density. Ultra-structural features are associated with changes in chromatin (e.g. reduction in heterochromatin and increase of perichromatin and interchromatin granules, formation of inclusions, and increase of nuclear membrane pores), invaginations, and nucleus segmentation.
The nucleus is characterized by its movement towards the membrane, hypertrophy, numerical increase, development of intranuclear and canalicular systems between the nucleolus and the nuclear membrane, and macro and micro-segregation. Mitoses are also a regular feature of malignant adipose tissue. Mitoses numerically increase, atypical mitosis forms with defects in the mitotic spindle develop, which produces dissymmetrical structures, triple or quadruple asters, and atypical forms of chromosomes. Nuclear changes justify genetic defects associated with these changes, and also explain the presence of different squamous cell clones. In malignant adipose tissue that are severely anaplastic, the presence of large nuclei and multinucleate squamous cells shows abnormal divisions (Hermans 2006, pg. 27). The morphological features discussed here symbolize the changes happening at metabolic level, with the augmentation of structures in regards to the ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
  • CHICAGO
(“Malignancy (Cellular Pathology) Case Study Example | Topics and Well Written Essays - 750 words”, n.d.)
Malignancy (Cellular Pathology) Case Study Example | Topics and Well Written Essays - 750 words. Retrieved from https://studentshare.org/biology/1634479-malignancy-cellular-pathology
(Malignancy (Cellular Pathology) Case Study Example | Topics and Well Written Essays - 750 Words)
Malignancy (Cellular Pathology) Case Study Example | Topics and Well Written Essays - 750 Words. https://studentshare.org/biology/1634479-malignancy-cellular-pathology.
“Malignancy (Cellular Pathology) Case Study Example | Topics and Well Written Essays - 750 Words”, n.d. https://studentshare.org/biology/1634479-malignancy-cellular-pathology.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document

CHECK THESE SAMPLES OF Malignancy (Cellular Pathology)

Cellular and Molecular ( Pathology Case Study Assignment)

...?Cellular and Molecular Pathology (Case Study Assignment) Tissue histopathological studies have become the gold standard for the diagnosis of a variety of liver diseases. According to the generally accepted criteria, following are the indications for liver biopsy: chronic hepatitis, Wilson`s disease, alcoholic hepatitis, non-alcoholic steatohepatitis, primary biliary cirrhosis, cholestatic liver disease, fever of unknown origin, liver mass, status of liver post-transplantation and of donor pre-transplantation (Bravo et al, 2001) Though it is generally accepted that liver biopsy specimen is no more than 1/150,000 part of the whole liver mass, but this is considered to be adequately representative of the...
6 Pages(1500 words)Essay

CELLULAR PATHOLOGY- Staining protocols

...? CELLULAR PATHOLOGY- Staining protocols Glycogen Glycogen is present in all the animals it the liver, with liver storing the glucose in the form of glycogen. Thus, during starvation or whenever glucose is required by the body, glycogen is converted back into glucose. Glycogen is preserved in the slides using the alcoholic preservation methods. The use of formalin solution will help to reduce the shrinkage and polarization of the tissue. Periodic Acid Schiff (PAS) stain is the most commonly used stain to identify the structures containing large amounts of glycogen, glycoprotein, mucin, proteoglycan and other basement membranes. (McGavin and Zachary 2006). Fig1: Periodic acid Schiff stain (PAS) of kidney....
3 Pages(750 words)Essay

CELLULAR PATHOLOGY- Staining protocols

...?Cellular Pathology experiment The aim of the practical was to look at sections of small intestine (ileum), kidney and liver. These are sections that were already processed to paraffin wax, sectioned, fixed as well as mounted on slides. Liver slides for glycogen and ileum slides for mucin staining (using Alcian Blue) were prepared as well with use of diastase digestion. Introduction The Periodic Acid Schiff (PAS) stain is a stain routinely employed in several cellular pathology laboratories. Several tissue components can be demonstrated by this stain. It is an important diagnostic tool in most clinical settings. Substances that consist of glycol groups or alkylamino and...
4 Pages(1000 words)Essay

Cellular and Molecular Pathology

...? Cellular and molecular pathology The most suitable method of removing adequate tissue for histopathological examinationand the most reliable way of making sure you get the correct tissue needed Materials to be used in histological preparations are removed from anaesthetized animals. Since this case involves a human being and thus human materials, which is a scarce situation. Surgical materials or rather tissues are the best source of human tissue due to the ability to remove the normal tissue together with the affected/diseased tissues. In obtaining the right tissue for the examination, there are two distinct methods that can be employed. That is the physical examination technique and the liver biopsy technique. During physical... -heme...
6 Pages(1500 words)Essay

CELLULAR PATHOLOGY CERVICAL CYTOLOGY

...CELLULAR PATHOLOGY CERVICAL CYTOLOGY OBSERVING THE COLOUR TRANSPARENCIES AND READING PRACTICAL SCHEDULE where is squamous epithelium located in the vagina and cervix [2 MARKS] Vagina - vaginal canal Cervix - exterior surface [2] where is the columnar epithelium located in the cervix [1 MARK] Endocervical canal [3] list some cell types found in a normal cervical smear [6 MARKS] Squamous cells - basal, parabasal, intermediate and superficial cells, columnar cells, blood cells [4] what colours do these cell types stain with the papanicolaou stain [6 MARKS] Parabasal - stain green [denser] Intermediate - stain green [ pale] Superficial - stain pink Basal cells - dense green Blood cells- orange [5] name some contaminants found... in...
2 Pages(500 words)Essay

Cellular pathology critical review assignment

...The article explores the role of the Human Papillomavirus (HPV) - E5 oncoprotein. While it has been shown that bovine E5 protein impairs the synthesis, stability and transport of the major histocompatibility (MHC) type I complex, this study shows that the E5 protein expressed by HPV-16 and the low-risk virus HPV-6 causes a similar retention of the MHC molecules. The novel mechanism identified here is that the HPV-16 E5 protein only prevents the transport of the MHC molecules to the cell surface by selectively down regulating the expression of HLA molecules A and B, which present viral peptides to the cytotoxic T-lymphocytes, thereby avoiding their clearance from the body which leads to establishment of infection and later...
2 Pages(500 words)Essay

Cellular pathology

...Cellular pathology Cellular pathology Gastritis is a condition with the lining of the stomach called mucosa that becomes inflamed. There are special cells contained on the stomach lining that produce enzymes and acid helping in the digestion and breakdown of food. The mucus from the acid protects the lining of the stomach and gastritis leads to less production of enzymes, acid and mucus. In the first section of the tissue examination, Haematoxylin and Eosin stain is used to give a good visibility of the cells and nucleus of the tissue and their activity state. Haematoxylin is a dye that is dark purple that will stain the nuclear material of the tissue making it a deep...
3 Pages(750 words)Essay

Cellular pathology 2

...CELLULAR PATHOLOGY 2 Subcutaneous tissue tumor (lipoma) Features that indicate a malignant diagnosis The micro description features that indicate the presence of the subcutaneous tissue includes mature white tissues of adipose that are without atypia. These tissues are free of any bonny cells and cartilage like structures. These cells are two to five times the size of a normal cell, and the appearance of the cells are large that can reach 300 microns. The cytoplasmic vacuoles of these cells appear relatively uniform, and intra-nuclear vacuoles are present. The cytoplasmic amount is small owing to the accumulation of messenger RNA and ribosomal RNA. Areas of fat necrosis on the tissue are seen with infarct and calcification setting... in. The...
3 Pages(750 words)Essay

Cellular pathology 1

...CELLULAR PATHOLOGY CELLULAR PATHOLOGY PATHOLOGICAL FEATURES The specimens have been stained with hematoxylin and eosin (H&E) which is the commonest stain used in light microscopy because it stains various structures quite simply(Ovalle et al, 2013, p.g.479). The diagrams show signs of inflammation. Mucosa is damaged and crypts can be seen. Neutrophil infiltration can also be appreciated in submucosa and muscularis externa. Diagram also shows aggregates of lymphoid follicles which can be appreciated by the purple colour they have taken up after staining. H&E staining have stained an organism in the second picture, which is enterrobius vermicularis. The...
3 Pages(750 words)Essay

Cellular pathology

...Cellular Pathology As a young aspiring scientist, I wish to obtain my Master’s Degree in Cellular Pathology from West of England University. Currently, I am a finalist in Biomedical Science level in the UK. Prior to my studies in UK, I attained an intermediate University Degree in Laboratory Sciences from college of health sciences. Upon graduating from college of sciences, I had the opportunity to work at King Abdul Aziz hospital in 2008. I aspire to continue with my studies in medical diagnostics at the University. Based on my laboratory science background and experience I obtained from King Abdul Aziz Hospital, I have confidence that I possess the necessary skills...
2 Pages(500 words)Personal Statement
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.

Let us find you another Case Study on topic Malignancy (Cellular Pathology) for FREE!

Contact Us